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Water solubility

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Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Qualifier:
according to
Guideline:
OECD Guideline 105 (Water Solubility)
GLP compliance:
no
Type of method:
flask method
Water solubility:
0.2 µg/L
Temp.:
21.5 °C
pH:
5.9
Remarks on result:
other: Cobalt metal powder C-1 concentration at 0 hour sampling time at 1 mg/L loading. Value given is average from triplicate tests.
Water solubility:
76.9 µg/L
Temp.:
21.5 °C
pH:
6.09
Remarks on result:
other: Cobalt metal powder C-1 concentration at 24 hour sampling time at 1 mg/L loading. Value given is average from triplicate tests.
Water solubility:
130 µg/L
Temp.:
21.6 °C
pH:
6.01
Remarks on result:
other: Cobalt metal powder C-1 concentration at 48 hour sampling time at 1 mg/L loading. Value given is average from triplicate tests.
Water solubility:
206 µg/L
Temp.:
21.6 °C
pH:
6.04
Remarks on result:
other: Cobalt metal powder C-1 concentration at 96 hour sampling time at 1 mg/L loading. Value given is average from triplicate tests.
Water solubility:
303 µg/L
Temp.:
21.5 °C
pH:
6.08
Remarks on result:
other: Cobalt metal powder C-1 concentration at 168 hour sampling time at 1 mg/L loading. Value given is average from triplicate tests.
Water solubility:
560 µg/L
Temp.:
21.5 °C
pH:
6.3
Remarks on result:
other: Cobalt metal powder C-1 concentration at 672 hour sampling time at 1 mg/L loading. Value given is average from triplicate tests.
Water solubility:
0.3 µg/L
Temp.:
21.5 °C
pH:
5.93
Remarks on result:
other: Cobalt metal powder C-1 concentration at 0 hour sampling time at 10 mg/L loading. Value given is average from triplicate tests.
Water solubility:
612 µg/L
Temp.:
21.6 °C
pH:
5.96
Remarks on result:
other: Cobalt metal powder C-1 concentration at 24 hour sampling time at 10 mg/L loading. Value given is average from triplicate tests.
Water solubility:
984 µg/L
Temp.:
21.6 °C
pH:
6.07
Remarks on result:
other: Cobalt metal powder C-1 concentration at 48 hour sampling time at 10 mg/L loading. Value given is average from triplicate tests.
Water solubility:
1 657 µg/L
Temp.:
21.7 °C
pH:
6.18
Remarks on result:
other: Cobalt metal powder C-1 concentration at 96 hour sampling time at 10 mg/L loading. Value given is average from triplicate tests.
Conclusions:
Under the conditions of the transformation/dissolution test, the dissolution of Cobalt metal powder C-1 is 560.0 µg/L at 1 mg/L loading for the 28-day endpoint.
The dissolution of Cobalt metal powder C-1 is 2445.0 µg/L at 10 mg/L loading for the 7-day endpoint.
The dissolution of Cobalt metal powder C-1 is 10967.0 µg/L at 100 mg/L loading for the 7-day endpoint.
Executive summary:
A seven day transformation/dissolution test according to the OECD guideline 29 and the GHS (Annex 10) protocol was run on Cobalt metal powder C-1 at a mass loading of 10 and 100 mg/L, at a pH of 6.0 Also a 28 day transformation/dissolution was run on Cobalt metal powder C-1 at a mass loading of 1 mg/L and at a pH of 6.0. Under the conditions of this test, the dissolution of Cobalt metal powder C-1 is 560.0 µg/L for the 28 -day endpoint (1 mg/L loading), 2445.0 µg/L for the 7 -day endpoint (10 mg/L loading) and 10967.0 µg/L for the 7 -day endpoint (100 mg/L loading).
Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Qualifier:
according to
Guideline:
OECD Guideline 105 (Water Solubility)
GLP compliance:
no
Type of method:
flask method
Water solubility:
2 445 µg/L
Temp.:
21.6 °C
pH:
6.18
Remarks on result:
other: Cobalt metal powder C-1 concentration at 168 hour sampling time at 10 mg/L loading. Value given is average from triplicate tests.
Water solubility:
0.3 µg/L
Temp.:
21.5 °C
pH:
5.9
Remarks on result:
other: Cobalt metal powder C-1 concentration at 0 hour sampling time at 100 mg/L loading. Value given is average from triplicate tests.
Water solubility:
2 684 µg/L
Temp.:
21.6 °C
pH:
6.27
Remarks on result:
other: Cobalt metal powder C-1 concentration at 24 hour sampling time at 100 mg/L loading. Value given is average from triplicate tests.
Water solubility:
4 583 µg/L
Temp.:
21.7 °C
pH:
6.38
Remarks on result:
other: Cobalt metal powder C-1 concentration at 48 hour sampling time at 100 mg/L loading. Value given is average from triplicate tests.
Water solubility:
7 707 µg/L
Temp.:
21.7 °C
pH:
6.58
Remarks on result:
other: Cobalt metal powder C-1 concentration at 96 hour sampling time at 100 mg/L loading. Value given is average from triplicate tests.
Water solubility:
10 967 µg/L
Temp.:
21.6 °C
pH:
6.72
Remarks on result:
other: Cobalt metal powder C-1 concentration at 168 hour sampling time at 1 mg/L loading. Value given is average from triplicate tests.
Conclusions:
Under the conditions of the transformation/dissolution test, the dissolution of Cobalt metal powder C-1 is 560.0 µg/L at 1 mg/L loading for the 28-day endpoint.
The dissolution of Cobalt metal powder C-1 is 2445.0 µg/L at 10 mg/L loading for the 7-day endpoint.
The dissolution of Cobalt metal powder C-1 is 10967.0 µg/L at 100 mg/L loading for the 7-day endpoint.
Executive summary:
A seven day transformation/dissolution test according to the OECD guideline 29 and the GHS (Annex 10) protocol was run on Cobalt metal powder C-1 at a mass loading of 10 and 100 mg/L, at a pH of 6.0 Also a 28 day transformation/dissolution was run on Cobalt metal powder C-1 at a mass loading of 1 mg/L and at a pH of 6.0. Under the conditions of this test, the dissolution of Cobalt metal powder C-1 is 560.0 µg/L for the 28 -day endpoint (1 mg/L loading), 2445.0 µg/L for the 7 -day endpoint (10 mg/L loading) and 10967.0 µg/L for the 7 -day endpoint (100 mg/L loading).
Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Qualifier:
according to
Guideline:
OECD Guideline 105 (Water Solubility)
GLP compliance:
no
Type of method:
flask method
Water solubility:
0.4 µg/L
Temp.:
21.5 °C
pH:
5.89
Remarks on result:
other: Cobalt metal powder C26-PTL concentration at 0 hour sampling time at 1 mg/L loading. Value given is average from triplicate tests.
Water solubility:
350.7 µg/L
Temp.:
21.6 °C
pH:
5.92
Remarks on result:
other: Cobalt metal powder C26-PTL concentration at 24 hour sampling time at 1 mg/L loading. Value given is average from triplicate tests.
Water solubility:
474.8 µg/L
Temp.:
21.5 °C
pH:
5.97
Remarks on result:
other: Cobalt metal powder C26-PTL concentration at 48 hour sampling time at 1 mg/L loading. Value given is average from triplicate tests.
Water solubility:
525.8 µg/L
Temp.:
21.4 °C
pH:
6.08
Remarks on result:
other: Cobalt metal powder C26-PTL concentration at 96 hour sampling time at 1 mg/L loading. Value given is average from triplicate tests.
Water solubility:
557.9 µg/L
Temp.:
21.4 °C
pH:
6.21
Remarks on result:
other: Cobalt metal powder C26-PTL concentration at 168 hour sampling time at 1 mg/L loading. Value given is average from triplicate tests.
Water solubility:
582.6 µg/L
Temp.:
21.5 °C
pH:
6.22
Remarks on result:
other: Cobalt metal powder C26-PTL concentration at 672 hour sampling time at 1 mg/L loading. Value given is average from triplicate tests.
Water solubility:
0.2 µg/L
Temp.:
21.6 °C
pH:
5.81
Remarks on result:
other: Cobalt metal powder C26-PTL concentration at 0 hour sampling time at 10 mg/L loading. Value given is average from triplicate tests.
Water solubility:
939 µg/L
Temp.:
21.5 °C
pH:
6.12
Remarks on result:
other: Cobalt metal powder C26-PTL concentration at 24 hour sampling time at 10 mg/L loading. Value given is average from triplicate tests.
Water solubility:
1 427 µg/L
Temp.:
21.6 °C
pH:
6.16
Remarks on result:
other: Cobalt metal powder C26-PTL concentration at 48 hour sampling time at 10 mg/L loading. Value given is average from triplicate tests.
Water solubility:
2 095 µg/L
Temp.:
21.3 °C
pH:
6.31
Remarks on result:
other: Cobalt metal powder C26-PTL concentration at 96 hour sampling time at 10 mg/L loading. Value given is average from triplicate tests.
Conclusions:
Under the conditions of the transformation/dissolution test, the dissolution of Cobalt metal powder C26-PTL is 582.6 µg/L at 1 mg/L loading for the 28-day endpoint.
The dissolution of Cobalt metal powder C26-PTL is 2414.0 µg/L at 10 mg/L loading for the 7-day endpoint.
The dissolution of Cobalt metal powder C26-PTL is 10681.0 µg/L at 100 mg/L loading for the 7-day endpoint.
Executive summary:
A seven day transformation/dissolution test according to the OECD guideline 29 and the GHS (Annex 10) protocol was run on Cobalt metal powder C26-PTL at a mass loading of 10 and 100 mg/L, at a pH of 6.0 Also a 28 day transformation/dissolution was run on Cobalt metal powder C26 -PTL at a mass loading of 1 mg/L and at a pH of 6.0. Under the conditions of this test, the dissolution of Cobalt metal powder C26 -PTL is 582.6 µg/L for the 28 -day endpoint (1 mg/L loading), 2414.0 µg/L for the 7 -day endpoint (10 mg/L loading) and 10681.0 µg/L for the 7 -day endpoint (100 mg/L loading).
Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Qualifier:
according to
Guideline:
OECD Guideline 105 (Water Solubility)
GLP compliance:
no
Type of method:
flask method
Water solubility:
2 414 µg/L
Temp.:
21.4 °C
pH:
6.57
Remarks on result:
other: Cobalt metal powder C26-PTL concentration at 168 hour sampling time at 10 mg/L loading. Value given is average from triplicate tests.
Water solubility:
0.2 µg/L
Temp.:
21.6 °C
pH:
5.83
Remarks on result:
other: Cobalt metal powder C26-PTL concentration at 0 hour sampling time at 100 mg/L loading. Value given is average from triplicate tests.
Water solubility:
3 565 µg/L
Temp.:
21.6 °C
pH:
6.35
Remarks on result:
other: Cobalt metal powder C26-PTL concentration at 24 hour sampling time at 100 mg/L loading. Value given is average from triplicate tests.
Water solubility:
5 749 µg/L
Temp.:
21.6 °C
pH:
6.47
Remarks on result:
other: Cobalt metal powder C26-PTL concentration at 48 hour sampling time at 100 mg/L loading. Value given is average from triplicate tests.
Water solubility:
8 803 µg/L
Temp.:
21.6 °C
pH:
6.74
Remarks on result:
other: Cobalt metal powder C26-PTL concentration at 96 hour sampling time at 100 mg/L loading. Value given is average from triplicate tests.
Water solubility:
10 681 µg/L
Temp.:
21.6 °C
pH:
6.93
Remarks on result:
other: Cobalt metal powder C26-PTL concentration at 168 hour sampling time at 100 mg/L loading. Value given is average from triplicate tests.
Conclusions:
Under the conditions of the transformation/dissolution test, the dissolution of Cobalt metal powder C26-PTL is 582.6 µg/L at 1 mg/L loading for the 28-day endpoint.
The dissolution of Cobalt metal powder C26-PTL is 2414.0 µg/L at 10 mg/L loading for the 7-day endpoint.
The dissolution of Cobalt metal powder C26-PTL is 10681.0 µg/L at 100 mg/L loading for the 7-day endpoint.
Executive summary:
A seven day transformation/dissolution test according to the OECD guideline 29 and the GHS (Annex 10) protocol was run on Cobalt metal powder C26-PTL at a mass loading of 10 and 100 mg/L, at a pH of 6.0 Also a 28 day transformation/dissolution was run on Cobalt metal powder C26 -PTL at a mass loading of 1 mg/L and at a pH of 6.0. Under the conditions of this test, the dissolution of Cobalt metal powder C26 -PTL is 582.6 µg/L for the 28 -day endpoint (1 mg/L loading), 2414.0 µg/L for the 7 -day endpoint (10 mg/L loading) and 10681.0 µg/L for the 7 -day endpoint (100 mg/L loading).
Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Qualifier:
according to
Guideline:
OECD Guideline 105 (Water Solubility)
GLP compliance:
no
Type of method:
flask method
Water solubility:
0.1 µg/L
Temp.:
21.5 °C
pH:
5.86
Remarks on result:
other: Cobalt metal powder PTL-29 concentration at 0 hour sampling time at 1 mg/L loading. Value given is average from triplicate tests.
Water solubility:
450 µg/L
Temp.:
21.6 °C
pH:
5.99
Remarks on result:
other: Cobalt metal powder PTL-29 concentration at 24 hour sampling time at 1 mg/L loading. Value given is average from triplicate tests.
Water solubility:
587 µg/L
Temp.:
21.6 °C
pH:
5.97
Remarks on result:
other: Cobalt metal powder PTL-29 concentration at 48 hour sampling time at 1 mg/L loading. Value given is average from triplicate tests.
Water solubility:
690 µg/L
Temp.:
21.6 °C
pH:
6
Remarks on result:
other: Cobalt metal powder PTL-29 concentration at 96 hour sampling time at 1 mg/L loading. Value given is average from triplicate tests.
Water solubility:
714 µg/L
Temp.:
21.5 °C
pH:
5.97
Remarks on result:
other: Cobalt metal powder PTL-29 concentration at 168 hour sampling time at 1 mg/L loading. Value given is average from triplicate tests.
Water solubility:
667 µg/L
Temp.:
21.6 °C
pH:
6.49
Remarks on result:
other: Cobalt metal powder PTL-29 concentration at 672 hour sampling time at 1 mg/L loading. Value given is average from triplicate tests.
Water solubility:
0.4 µg/L
Temp.:
21.5 °C
pH:
5.91
Remarks on result:
other: Cobalt metal powder PTL-29 concentration at 0 hour sampling time at 10 mg/L loading. Value given is average from triplicate tests.
Water solubility:
1 458 µg/L
Temp.:
21.6 °C
pH:
6.03
Remarks on result:
other: Cobalt metal powder PTL-29 concentration at 24 hour sampling time at 10 mg/L loading. Value given is average from triplicate tests.
Water solubility:
2 199 µg/L
Temp.:
21.6 °C
pH:
6.17
Remarks on result:
other: Cobalt metal powder PTL-29 concentration at 48 hour sampling time at 10 mg/L loading. Value given is average from triplicate tests.
Water solubility:
2 952 µg/L
Temp.:
21.7 °C
pH:
6.17
Remarks on result:
other: Cobalt metal powder PTL-29 concentration at 96 hour sampling time at 10 mg/L loading. Value given is average from triplicate tests.
Conclusions:
Under the conditions of the transformation/dissolution test, the dissolution of Cobalt metal powder PTL-29 is 667.0 µg/L at 1 mg/L loading for the 28-day endpoint.
The dissolution of Cobalt metal powder PTL-29 is 3495.0 µg/L at 10 mg/L loading for the 7-day endpoint.
The dissolution of Cobalt metal powder PTL-29 is 12780.0 µg/L at 100 mg/L loading for the 7-day endpoint.
Executive summary:
A seven day transformation/dissolution test according to the OECD guideline 29 and the GHS (Annex 10) protocol was run on Cobalt metal powder PTL-29 at a mass loading of 10 and 100 mg/L, at a pH of 6.0 Also a 28 day transformation/dissolution was run on Cobalt metal powder PTL-29 at a mass loading of 1 mg/L and at a pH of 6.0. Under the conditions of this test, the dissolution of Cobalt metal powder PTL-29 is 667.0 µg/L for the 28 -day endpoint (1 mg/L loading), 3495.0 µg/L for the 7 -day endpoint (10 mg/L loading) and 12780.0 µg/L for the 7 -day endpoint (100 mg/L loading).
Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Qualifier:
according to
Guideline:
OECD Guideline 105 (Water Solubility)
GLP compliance:
no
Type of method:
flask method
Water solubility:
3 495 µg/L
Temp.:
21.6 °C
pH:
6.25
Remarks on result:
other: Cobalt metal powder PTL-29 concentration at 168 hour sampling time at 10 mg/L loading. Value given is average from triplicate tests.
Water solubility:
0.8 µg/L
Temp.:
21.5 °C
pH:
6.01
Remarks on result:
other: Cobalt metal powder PTL-29 concentration at 0 hour sampling time at 100 mg/L loading. Value given is average from triplicate tests.
Water solubility:
4 150 µg/L
Temp.:
21.6 °C
pH:
6.38
Remarks on result:
other: Cobalt metal powder PTL-29 concentration at 24 hour sampling time at 100 mg/L loading. Value given is average from triplicate tests.
Water solubility:
6 630 µg/L
Temp.:
21.6 °C
pH:
6.57
Remarks on result:
other: Cobalt metal powder PTL-29 concentration at 48 hour sampling time at 100 mg/L loading. Value given is average from triplicate tests.
Water solubility:
10 719 µg/L
Temp.:
21.7 °C
pH:
6.68
Remarks on result:
other: Cobalt metal powder PTL-29 concentration at 96 hour sampling time at 100 mg/L loading. Value given is average from triplicate tests.
Water solubility:
12 780 µg/L
Temp.:
21.6 °C
pH:
6.9
Remarks on result:
other: Cobalt metal powder PTL-29 concentration at 168 hour sampling time at 100 mg/L loading. Value given is average from triplicate tests.
Conclusions:
Under the conditions of the transformation/dissolution test, the dissolution of Cobalt metal powder PTL-29 is 667.0 µg/L at 1 mg/L loading for the 28-day endpoint.
The dissolution of Cobalt metal powder PTL-29 is 3495.0 µg/L at 10 mg/L loading for the 7-day endpoint.
The dissolution of Cobalt metal powder PTL-29 is 12780.0 µg/L at 100 mg/L loading for the 7-day endpoint.
Executive summary:
A seven day transformation/dissolution test according to the OECD guideline 29 and the GHS (Annex 10) protocol was run on Cobalt metal powder PTL-29 at a mass loading of 10 and 100 mg/L, at a pH of 6.0 Also a 28 day transformation/dissolution was run on Cobalt metal powder PTL-29 at a mass loading of 1 mg/L and at a pH of 6.0. Under the conditions of this test, the dissolution of Cobalt metal powder PTL-29 is 667.0 µg/L for the 28 -day endpoint (1 mg/L loading), 3495.0 µg/L for the 7 -day endpoint (10 mg/L loading) and 12780.0 µg/L for the 7 -day endpoint (100 mg/L loading).
Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
key study
Study period:
2009-02-25 to 2009-03-24
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: GLP guideline study reliable without restrictions - The stability of the test substance is missing.
Qualifier:
according to
Guideline:
OECD Guideline 105 (Water Solubility)
Version / remarks:
adopted July 27, 1995
Deviations:
no
Qualifier:
according to
Guideline:
other: Council regulation (EC) No. 440/2008, A.6 "Water solubility", adopted 30 May 2008
Deviations:
no
GLP compliance:
yes (incl. certificate)
Remarks:
signed 2008-11-12
Type of method:
column elution method
Water solubility:
0.07 mg/L
Temp.:
37 °C
pH:
ca. 8.61
Water solubility:
2.94 mg/L
Temp.:
20 °C
pH:
ca. 7.72
Conclusions:
Interpretation of results (migrated information): slightly soluble (0.1-100 mg/L)
During this study the water solubility of Cobalt Powder (Extra Fine HDFP) at 20 °C was determined using the column elution method and was found to be 2.94 mg/L.

Description of key information

The water solubility of cobalt (GLP and guideline study): at 20 °C = 2.94 mg/L, at 37 °C = 0.07 mg/L.

Key value for chemical safety assessment

Water solubility:
2.94 mg/L
at the temperature of:
20 °C

Additional information

The water solubility of the cobalt metal was determined according to OECD guideline 105 with the column elution method. During this study the water solubility of Cobalt Powder (Extra Fine HDFP) at 20 °C was found to be 2.94 mg/L.