Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 231-158-0 | CAS number: 7440-48-4
Acute oral toxicity:LD50(male and female)=550 mg Co/kg bwAcute toxicity, inhalation:LC100(male and female)<50 µg Co/LAcute toxicity, dermal:Conduct of an acute dermal toxicity study is unjustified, since a dermal absorption study as well as the physicochemical properties of the substance do not suggest a significant rate of absorption through the skin (cf. Annex VIII section 8.5 Column 2 of regulation (EC) 1907/2006).
The reference Durando (2013) is considered as the key study for acute oral toxicity and will be used for classification. The test was conducted according to OECD 425. The LD50 for female rats was calculated to be 550 mg/kg bw
The classification criteria according to regulation (EC) 1272/2008 as acutely toxic category 4 (CLP) are met since the ATE is between 300 and 2000 mg/kg body-weight. Cobalt metal will be classified in accordance with regulation (EC) 1272/2008 as acutely toxic category 4 (H302) and in accordance with 67/548/EEC as harmful if swallowed (R22).
Specific target organ toxicant (STOT) – single exposure: oral
The classification criteria acc. to regulation (EC) 1272/2008 as specific target organ toxicant (STOT) – single exposure, oral are not met since no reversible or irreversible adverse health effects were observed immediately or delayed after exposure and no effects were observed at the guidance value, oral for a Category 1 classification of 300 mg/kg bw and at the guidance value, oral for a Category 2 classification of 2000 mg/kg bw. No classification required.
Acute dermal toxicity
Conduct of an acute dermal toxicity study for cobalt is unjustified since dermal uptake is considered negligible.
Specific target organ toxicant (STOT) – single exposure: dermal
Acute inhalation toxicity and Specific target organ toxicant (STOT) – single exposure: inhalation
The reference Haferkorn (2012) is considered as the key study for acute inhalation toxicity and will be used for classification. In this study (OECD 436, EU B.2, under GLP) rats were exposed with a fine cobalt metal powder (D50=2.4μm, MMAD=2.75-3.26μm GSD=2.75-3.26) lethal effects were seen at a concentration of 0.05 mg/L, leading to premature death of all animals until day 11 post exposure. The lethal effects were caused by an acute inflammatory response in all lobes of the lung, including perivascular oedema.
The classification criteria according to regulation (EC) 1272/2008 as acutely toxic via inhalation category 1 (H330) are met for respirable cobalt metal powder. The classification criteria according to directive 67/548/EEC as very toxic by inhalation (R26) are met for respirable cobalt metal powder. It is reasonable to assume that all cobalt metal powders with similar potential for deposition in the pulmonary region of the respiratory tract would elicit similar effects and would require classification accordingly. Further details on the classification criteria of cobalt metal powders are given in the document attached to the endpoint summary in IUCLID section 7.2.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
Welcome to the ECHA website. This site is not fully supported in Internet Explorer 7 (and earlier versions). Please upgrade your Internet Explorer to a newer version.
Close Do not show this message again