Registration Dossier
Registration Dossier
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EC number: 700-825-2 | CAS number: -
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
In a 96h acute toxicity limit test conducted according to the OECD guideline 203, zebrafish (Danio rerio) were exposed to E99434 at nominal loading rate of 100 mg/L under semi-static conditions for the period of 96 hours. Neither clinical signs nor mortality could be observed throughout the study.
Based on the results of this study, the LL50 of E99434 was determined to be >100 mg test item/L. The NOELR based on the visual observation is reported as 100 mg/L.
Key value for chemical safety assessment
Additional information
An experimental study was performed to determine the acute toxicity of E99434 to zebrafish (Danio rerio). The study was conducted according to the OECD guideline 203. Due to the negligible water solubility of test substance, a Water Accommodated Fraction (WAF) of the test substance was applied. The test substance was tested in a limit test at the nominal loading rate of 100 mg test item/L under semi-static conditions for 96 hours. Untreated dilution water was run in parallel as a control. Seven fish each were used at the test concentration and in the control.
There were no toxic effects of the test item on zebrafish (Danio rerio) at the nominal loading rate of 100 mg test item/L. No clinical signs or mortality were observed throughout the study. Thus, no toxicity effect value for acute toxicity was calculated. The lethal level 50 % (LL50) based on the nominal loading was determined to be >100 mg/L. The NOEL based on the visual observation is reported as 100 mg/L.
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