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EC number: 202-468-3 | CAS number: 95-96-5
Particle size distribution (Granulometry)
Administrative data
Link to relevant study record(s)
- Endpoint:
- particle size distribution (granulometry)
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- weight of evidence
- Justification for type of information:
- For details and justification of read-across please refer to the read-across report attached to IUCLID section 13.
- Reason / purpose for cross-reference:
- read-across source
- Mass median aerodynamic diameter:
- ca. 308 µm
- Geometric standard deviation:
- >= 2.82 - <= 2.92
- Percentile:
- D10
- Mean:
- 66 µm
- St. dev.:
- 0.97
- Key result
- Percentile:
- D50
- Mean:
- 267 µm
- St. dev.:
- 6.3
- Percentile:
- D90
- Mean:
- 1 426 µm
- St. dev.:
- 4.6
- Conclusions:
- In conclusion, it can be stated that a manual sieve analysis indicated that 99.1% by weight of the sample had a particle size of <2000 µm. A subsequent laser diffraction analysis on the <2000 µm sample revealed that the median (d50) was 267 µm.
- Executive summary:
In summary, the laser diffraction test conducted to determine the Particle size analysis produced the following results: Manual sieve analysis indicated that 99.1% by weight of the sampe had a particle size of <2000 µm. A subsequent laser diffraction analysis on the <2000 µm sample revealed that the median size (d50) was 267 µm and that the mass median aerodynamic diameter (MMAD) was 308 µm.
This information is used in a read-across approach in the assessment of the target substance. For justification of read-across please refer to the attached read-across report (see IUCLID section 13).
- Endpoint:
- particle size distribution (granulometry)
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- weight of evidence
- Justification for type of information:
- For details and justification of read-across please refer to the read-across report attached to IUCLID section 13.
- Reason / purpose for cross-reference:
- read-across source
- Mass median aerodynamic diameter:
- ca. 262 µm
- Geometric standard deviation:
- >= 2.97 - <= 3.07
- Percentile:
- D10
- Mean:
- 49 µm
- St. dev.:
- 0.94
- Key result
- Percentile:
- D50
- Mean:
- 229 µm
- St. dev.:
- 2.56
- Percentile:
- D90
- Mean:
- 622 µm
- St. dev.:
- 7.92
- Conclusions:
- A manual sieve analysis indicated that 95.6% by weight of the sample had a particle size of < 2000 µm. A subsequent laser diffraction analysis on the < 2000 µm sample revealed that the median size (d50) was 229 µm.
- Executive summary:
In summary, the laser diffraction test conducted to determine the particle size distribution produced the following results: Manual sieve analysis indicated that 95.6% by weight of the sampe had a particle size of < 2000 µm. A subsequent laser diffraction analysis on the < 2000 µm sample revealed that the median size (D50) was 229 µm and that the mass median aerodynamic diameter (MMAD) was 262 µm.
This information is used in a read-across approach in the assessment of the target substance. For justification of read-across please refer to the attached read-across report (see IUCLID section 13).
Referenceopen allclose all
Average (µm)
Volume weighted mean: 578.7 µm
Median (D50): 267.0 µm
Mode: 1206 µm
MMAD (Mass Median Aerodynamic Diameter): 308.0 µm
10 % of material is 66.4 µm
50 % of material is 267.0 µm
90 % of material is 1426 µm
1.87 % by volume of sample was seen to be <10 µm
Average (µm)
Volume weighted mean: 288 µm
Median (D50): 229 µm
Mode: 472 µm
MMAD (Mass Median Aerodynamic Diameter): 262 µm
10 % of material is 49 µm
50 % of material is 229 µm
90 % of material is 622 µm
2.67 % by volume of sample was <10 µm
Description of key information
For L- and D-lactide, the MMAD were 308 and 262 µm, the median size (d50) was 267 and 229 µm. There is no reason why the particle size distribution of dilactide would differ from that of L- or D-lactide, as dilactide is a mixture of D-and L-lactide isomers.
ers.
Additional information
There is no reason why the particle size distribution of dilactide would differ from that of L- or D-lactide. D- and L-lactide are suitable read across partner as dilactide is a mixture of D- and L-lactide isomers.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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