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Description of key information

Assessment of the acute oral toxicity of zinc nitrate was studied in Wistar CRL/WI rats according to OECD guideline no 423 (Acute toxic Class Method) .The LD50 value was established to be greater than 300 mg/kg bw but less than 2000 mg/kg bw.
There are no specific data for zinc nitrate available on which to evaluate for acute inhalation and dermal toxicity. Read-across towards soluble zinc chloride and zinc sulphate, indicates that zinc nitrate is of very low dermal toxicity not requiring a classification according to the EC criteria. No reliable guideline study on read-across substances is available for inhaltion toxicity. Some published information are available on the soluble read-across substances zinc chloride and zinc sulphate, however these data are not suitable for classification.


Key value for chemical safety assessment

Acute toxicity: via oral route

Endpoint conclusion
Endpoint conclusion:
adverse effect observed
Dose descriptor:
LD50
Value:
300 mg/kg bw

Acute toxicity: via inhalation route

Endpoint conclusion
Endpoint conclusion:
no study available

Acute toxicity: via dermal route

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed
Dose descriptor:
LD50
Value:
2 000 mg/kg bw

Additional information

Zinc chloride demonstrated acute toxicity via the inhalation route (LC50≤ 1,975 mg/m3). However, since the exposure of the animals to the size of the particles is not truly representative of exposure to humans under normal conditions, it is difficult to assess whether or not, zinc chloride is acutely toxic since a four hour LC50value could not be derived and a clear dose-response relationhip coud not be established. Airway irritation has been observed both in animals and in humans, zinc chloride has the potential to be a respiratory tract irritant. In conclusion, the study cannot be used to assess the acute inhalation toxicity of zinc nitrate.

Zinc sulphate is not acutely toxic via the dermal route (LD50 >2,000 mg/kg bw). Effects of inhalation exposure to zinc sulphate were limited to pulmonary effects only.

Justification for classification or non-classification

Soluble zinc nitrate is harmful following acute oral exposure (300 > LD50 < 2000 mg/kg bw) and meets the classification criteria for harmful if swallowed: Acute Tox. Cat. 4: H332.

There are no specific data for zinc nitrate available on which to evaluate for acute inhalation and dermal toxicity. Read-across towards soluble zinc chloride and zinc sulphate, indicates that zinc nitrate is of very low dermal toxicity not requiring a classification according to the EC criteria.