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Description of key information

Determination of the Hydrolysis values of p-(2,3-epoxypropoxy)-N,N-bis(2,3-epoxypropyl)aniline (496981)
(GLP compliant study based on the OECD Guideline 111, 2004 and EEC 440/2008 Guideline C.7).
Author: Dr. Ir. E. Baltussen

Key value for chemical safety assessment

Half-life for hydrolysis:
2.3 d
at the temperature of:
25 °C

Additional information

Hydrolysis of p-(2,3-epoxypropoxy)-N,N-bis(2,3-epoxypropyl)aniline was studied at 20, 40 and 50 ºC in sterile aqueous buffered solutions at pH 4, pH 7 and pH 9.  The hydrolysis at 25oC was estimated based on the Arrheniusequation.

The experiment was conducted in accordance with the EEC directive 440/2008, Guideline C.7 “Degradation - Abiotic Degradation : Hydrolysis as a Function of pH”, and the OECD Guideline 111 "Hydrolysis as a Function of pH”, adopted in April 2004 and in compliance with the GLP standards.


Samples were analysed by HPLC. 

pH 4 pH 7 pH 9
Temperature [°C] Temperature [°C] Temperature [°C]
20 3.9 d 20 4.1 d 20 4.6 d
25 2.2 d 25 2.3 d 25 2.6 d
40 10 h 40 10 h 40 12 h
50 3.9 h 50 4.3 h 50 5.7 h