Registration Dossier
Registration Dossier
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EC number: 229-177-4 | CAS number: 6422-99-7
Biodegradation in water: screening tests
Administrative data
Link to relevant study record(s)
Description of key information
Sebacid acid, compound with hexane-1,6-diamine is readily biodegradable.
Key value for chemical safety assessment
- Biodegradation in water:
- readily biodegradable
Additional information
The 2015 experimental study was performed in compliance with GLP according to OECD 301B method. This study was scored as Klimisch 1 and concludes that sebacic acid, compound with hexane-1,6-diamine is readily biodegradable. Another study, performed in 2013, was available. It is GLP-compliant and performed according to OECD 301D. However, this study was scored as Klimisch 2 due to the fact that a discontinuity was observed on the biodegradation curves (see the Endpoint Study Record entitled "Biodeg SS V2 2013 HARLAN" for further details). This study concludes that sebacic acid, compound with hexane-1,6-diamine is not readily biodegradable. It has to be considered that ready biodegradability tests as OECD 301 studies presents very stringent experimental conditions: the test substance is the only source of carbon in the test medium, inoculum is present at low concentrations and the test duration is limited to 28 days. Therefore and in accordance with ECHA Guidance R7b, consistent positive test results should generally supersede negative test results. For this reason and considering the difference of reliability between both studies, the 2015 study was flagged as the key study and the 2013 study as the supporting study.
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