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EC number: 229-177-4 | CAS number: 6422-99-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Short observation period; limited documentation; however, basic data are given.
Cross-reference
- Reason / purpose for cross-reference:
- reference to other study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 956
- Report date:
- 1956
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- not specified
- Principles of method if other than guideline:
- The test substance was administered via single dose gavage to groups of one or five animals per dose level. Animals were observed approximately 1-3 hours after dosing and then daily over a period of 8 days. At necropsy, all rats were examined for gross pathological changes.
- GLP compliance:
- no
- Remarks:
- pre-GLP study
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Adipic acid, compound with hexane-1,6-diamine (1:1)
- EC Number:
- 222-037-3
- EC Name:
- Adipic acid, compound with hexane-1,6-diamine (1:1)
- Cas Number:
- 3323-53-3
- IUPAC Name:
- hexanedioic acid - hexane-1,6-diamine (1:1)
- Reference substance name:
- Adipic acid, compound with hexane-1,6-diamine
- IUPAC Name:
- Adipic acid, compound with hexane-1,6-diamine
- Details on test material:
- - Name of test material (as cited in study report): AH-Salz trocken (hexamethylenediamine adipate, dry)
No further data.
The justification of the read-accross is fully detailed in the endpoint summary.
Constituent 1
Constituent 2
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Breeder
- Fasting period before study: yes
- Diet: ad libitum
- Water: ad libitum
- Acclimation period: 1 week
ENVIRONMENTAL CONDITIONS
- Photoperiod (hrs dark / hrs light): 12h/12h
Administration / exposure
- Route of administration:
- oral: unspecified
- Vehicle:
- not specified
- Doses:
- 500, 1000, 2000, 4000, 5000, 8000, 10000 mg/kg bw
- No. of animals per sex per dose:
- 1 or 5 animals per dose
- Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: 8 days
- Frequency of observations: approximately 1-3 hours after dosing and then daily over a period of 8 days
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, gross pathology
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- approximate LD50
- Effect level:
- ca. 4 900 mg/kg bw
- Based on:
- test mat.
- Mortality:
- All but one of the animals given 5000 mg/kg bw and more died; late deaths were observed. See table 7.2.1/1.
- Clinical signs:
- other: Lethal doses caused seizures. Sublethal doses led to stiff gait, apathy, reduced appetite, diarrhoea, and rough coat.
- Gross pathology:
- At necropsy, signs of gastro-intestinal tract irritation and intestinal bleeding were found.
Any other information on results incl. tables
Table 7.2.1/1: mortality data
Dose [mg/kg] |
Mortality rate |
Death occurred within |
10000 |
1/1 |
3 hours |
8000 |
5/5 |
1-2 days |
5000 |
4/5 |
1-8 days |
4000 |
0/5 |
|
2000 |
0/1 |
|
1000 |
0/1 |
|
500 |
0/1 |
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Under the test conditions, the test item is not classified for acute oral toxicity in rats as LD50 is higher than 2000 mg/kg bw.
- Executive summary:
In an acute oral toxicity study (BASF, 1956), groups of 1 to 5 rats were given a single dose of Hexamethylenediamine adipate, dry (purity not given) at doses of 500, 1000, 2000, 4000, 5000, 8000, and 100000 mg/kg bw and were observed for 8 days. Necropsy was performed at the end of the study.
All but one of the animals given 5000 mg/kg bw and more died; late deaths were observed. Lethal doses caused seizures. Sub-lethal doses led to stiff gait, apathy, reduced appetite, diarrhea, and rough coat. At necropsy, signs of gastro-intestinal tract irritation and intestinal bleeding were found.
Based on this study,the oral LD50 in rats was approximately 4900 mg/kg bw.
Under the test conditions, the test substance is not classified for acute oral toxicity according to the Regulation (EC) 1272/2008 (CLP) and the Directive 67/548/EEC criteria, as for sebacic acid, compound with hexane-1,6 -diamine (1:1), considering the read-accross approach.
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