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Ecotoxicological information

Toxicity to birds

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Administrative data

Endpoint:
short-term toxicity to birds: dietary toxicity test
Type of information:
migrated information: read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Basic data given, acceptable study which meets basic scientific principles.

Data source

Reference
Reference Type:
publication
Title:
Use of High Leveis of Dietary Aluminum and Zinc for Inducing Pauses in Egg Production of Japanese Quail.
Author:
Hussein AS et al.
Year:
1988
Bibliographic source:
Poultry Science 67: 1157-1165

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
The study was conducted in three different trials. The objective of the first trial was to compare the effects of high levels of dietary Al and Zn upon induction of pauses in egg production and subsequent performance of Japanese quail laying hens. The objective of the second trail was to determine the effect of dietary Zn and Al in combination with decreased day length for inducing pauses in egg production. The objective of Trial 3 was to determine the influence of graded levels of dietary Al on the performance of Japanese quail laying hens using levels lower then 0.3% Al in order to prevent complete cessation of egg production.
GLP compliance:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
- Chemical name: Aluminium sulphate
- Analytical Purity: no data
Dose method:
feed
Analytical monitoring:
no
Vehicle:
no

Test organisms

Test organisms (species):
Coturnix coturnix japonica

Study design

Limit test:
no
Total exposure duration (if not bolus):
28 d

Results and discussion

Effect levelsopen allclose all
Duration (if not bolus):
28 d
Dose descriptor:
NOEL
Effect level:
5 000 mg/kg diet
Conc. / dose based on:
element
Remarks:
Al
Basis for effect:
other: egg shell breaking strength, body weight, feed intake
Remarks on result:
other: =0.05% Al in diet
Duration (if not bolus):
28 d
Dose descriptor:
NOEL
Effect level:
24 709 mg/kg diet
Conc. / dose based on:
test mat.
Remarks:
AlCl3
Basis for effect:
other: egg shell breaking strength, body weight, feed intake
Remarks on result:
other: =0.05% Al in diet

Any other information on results incl. tables

The effect of using a high level of dietary aluminium (0.3% AI, as aluminum sulfate) was investigated among 4 and 7 days. Results showed that Al treatments significantly (P<0.05) reduced body weight. Egg production approached 0% by Day 3. Egg shell breaking strength was significantly (P<0.05) reduced by dietary Al. Aluminum significantly reduced plasma inorganic P, measured on day 5. In Trial 3 (28 day study), diets containing graded levels (0, 0.05, 0.10, or 0.15%) of Al were fed to Japanese quail hens for 28 days. Both 0.10% and 0.15% Al significantly (P<0.05) reduced egg shell breaking strength during Days 8 through 12 and body weight at Day 28. Feeding 0.15% Al significantly reduced feed intake and egg production.

Applicant's summary and conclusion