Registration Dossier
Registration Dossier
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EC number: 231-208-1 | CAS number: 7446-70-0
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: basic information given; short study description; results only in tabular form
Data source
Reference
- Reference Type:
- publication
- Title:
- Acute Toxicity Tests on 113 Environmental Chemicals.
- Author:
- Hasegawa, B., Nakaji, Y., Kurokawa, Y., Tobe, M.
- Year:
- 1 989
- Bibliographic source:
- Sci. Rep. Res. Inst. Toboku Univ. 36, 10-16
Materials and methods
- Principles of method if other than guideline:
- The fifty percent of lethal dose (LD50) was calculated using the Litchfield and Wilcoxon method.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Aluminium chloride
- EC Number:
- 231-208-1
- EC Name:
- Aluminium chloride
- Cas Number:
- 7446-70-0
- Molecular formula:
- AlCl3
- IUPAC Name:
- trichloroalumane
- Details on test material:
- highest purity available
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- Male and female animals (5 weeks of age) were used after an acclimatization for 1 week. Ten animals were used for each dosing and at
least 6 increasing dose levels were selected and tested to confirm the LD50 value.
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- water
- Details on oral exposure:
- Test solutions were administered orally after 15 hours of food deprivation. Clinical signs and symptoms were monitored during the experimental period. Animals were given regular laboratory chow 6 hr after a single administration and the number of dead animals were counted until the 14th day. Anatomical examination was performed immediately after death or at terminal sacrifice on day 14.
The fifty percent of lethal dose was calculated using the Litchfield and Wilcoxon method. - Doses:
- 6 increasing dose levels
- No. of animals per sex per dose:
- total: 60
- Control animals:
- not specified
Results and discussion
Effect levelsopen allclose all
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 3 450 mg/kg bw
- 95% CL:
- 2 900 - 4 110
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- 3 470 mg/kg bw
- 95% CL:
- 2 630 - 4 580
- Mortality:
- no data
- Clinical signs:
- other: hematuria, blood stool
- Gross pathology:
- no data
- Other findings:
- congestion of stomach and brain
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
