Registration Dossier
Registration Dossier
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EC number: 203-398-6 | CAS number: 106-44-5
Toxicity to reproduction: other studies
Administrative data
- Endpoint:
- toxicity to reproduction: other studies
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: guideline study: examination of reproductive organs
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 991
Materials and methods
- Principles of method if other than guideline:
- The reproductive organs were examined as part of the 28-day study.
- GLP compliance:
- yes
- Type of method:
- in vivo
Test material
- Reference substance name:
- p-cresol
- EC Number:
- 203-398-6
- EC Name:
- p-cresol
- Cas Number:
- 106-44-5
- Molecular formula:
- C7H8O
- IUPAC Name:
- p-cresol
- Details on test material:
- Test substance: other TS: p-cresol, Purity > 98 %
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- B6C3F1
- Sex:
- male/female
Administration / exposure
- Route of administration:
- oral: feed
- Details on exposure:
- see section 7.5.1
- Duration of treatment / exposure:
- 28 d
- Frequency of treatment:
- continuously in diet
Doses / concentrations
- Remarks:
- Doses / Concentrations:
0, 300, 1000, 3000, 10000, 30000 ppm
Basis:
- Control animals:
- yes, concurrent no treatment
- Details on study design:
- Duration of test: 28 d
Results and discussion
Effect levels
- Dose descriptor:
- NOAEL
- Effect level:
- 2 060 mg/kg bw/day
- Based on:
- test mat.
- Sex:
- male
Observed effects
Any other information on results incl. tables
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
