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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
supporting study
Study period:
no data
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Limited publication.

Data source

Reference
Reference Type:
publication
Title:
The place of the range-finding test in the industrial toxicology laboratory.
Author:
Smyth, H.F. Jr., Carpenter, C.P.
Year:
1944
Bibliographic source:
J IND HYG 26:269-273, 1944.

Materials and methods

Principles of method if other than guideline:
no information

Test material

Constituent 1
Chemical structure
Reference substance name:
Citraconic anhydride
EC Number:
210-459-0
EC Name:
Citraconic anhydride
Cas Number:
616-02-4
Molecular formula:
C5H4O3
IUPAC Name:
3-methyl-2,5-dihydrofuran-2,5-dione
Details on test material:
citraconic anhydride

Test animals

Species:
guinea pig

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
1 mL/kg bw

Applicant's summary and conclusion

Interpretation of results:
study cannot be used for classification
Conclusions:
LD50 1ml/kg bw (rel. density = 1.25 ~ 1250 mg/kg bw)
Executive summary:

LD50 1ml/kg bw (rel. density = 1.25 ~ 1250 mg/kg bw)