Registration Dossier
Registration Dossier
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EC number: 201-143-3 | CAS number: 78-79-5
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
The 96 hour LC50 for acute toxicity to fish is 7.43 mg/L. TLM QSAR modelling was used to calculate LL50 value of isoprene towards fish. The calculated LL50 is 17.158 mg/L.
The lowest value was used for chemical safety assessment.
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Effect concentration:
- 7.43 mg/L
Additional information
Huntingdon Life Sciences (2004) reports a 96-hour LC50 value of 7.43 mg/L for the freshwater fish Oncorhynchus mykiss in a standard OECD 203 test. This result was from a study using a daily static renewal with daily analytical confirmation of the exposure concentrations. The result is based on the geometric mean of measured exposure concentrations. This study was conducted under GLP to standard guidelines. It was listed as Klimisch 1 in the OECD SIDS for isoprene and was also used by the Olefins Panel of the American Chemistry Council in the Category Summary for C5 non-cyclics for the US High Production Volume Chemical Program. Additional data for isoprene are available from regulatory documents and QSARs.
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