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Registration Dossier
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EC number: 231-146-5 | CAS number: 7440-36-0
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Reference do not give sufficient experimental details: longer exposure time than recommended by OECD 404, 2002; no details on test material, test animals and little information on administration
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 955
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- The day before administration the eight albino rabbits were clipped over the entire trunk, care being taken to avoid cutting or abrading the skin. A single dose of 25g antimony trioxide dust incorporated in aqueous methylcellulose paste was applied to the denuded skin. The test site areas were about two-thirds of the animals`torso. They were covered by an impervious membrane (Vinylite). The test item was applied for one week. After exposure local skin reactions and signs of systemic toxicity were examined.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Diantimony trioxide
- EC Number:
- 215-175-0
- EC Name:
- Diantimony trioxide
- Cas Number:
- 1309-64-4
- Molecular formula:
- Sb2O3
- IUPAC Name:
- dioxodistiboxane
- Test material form:
- not specified
Constituent 1
Test animals
- Species:
- other: albino rabbits
- Strain:
- not specified
- Details on test animals or test system and environmental conditions:
- no data
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- other: clipped over the entire trunk without cutting the skin
- Vehicle:
- other: aqueous methylcellulose paste
- Controls:
- not specified
- Amount / concentration applied:
TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 25 g of antimony trioxide dust incorporated in aqueous methylcellulose paste
- Concentration (if solution): not stated
VEHICLE
- Amount(s) applied (volume or weight with unit): not stated
- Concentration (if solution): not stated
- Lot/batch no. (if required): not stated
- Purity:not stated- Duration of treatment / exposure:
- one week
- Observation period:
- not stated
- Number of animals:
- eight albino rabbits
- Details on study design:
- TEST SITE
- Area of exposure: The Methylcellulose paste was applied to the intact skin of two-thirds of the animals' torso.
- Type of wrap if used: The area was covered by an impervious membrane (Vinylite).
Results and discussion
In vivo
Results
- Irritation parameter:
- overall irritation score
- Basis:
- other: Overall assessment
- Time point:
- other: Not specified
- Score:
- 0
- Max. score:
- 0
- Reversibility:
- not specified
- Remarks on result:
- no indication of irritation
- Irritant / corrosive response data:
- No significant local reaction.
- Other effects:
- No apparent sign of systemic toxicity.
Any other information on results incl. tables
No significant local reaction. No apparent sign of systemic toxicity.
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: expert judgment
- Conclusions:
- No significant local reaction.
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