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EC number: 805-711-7 | CAS number: 1006899-79-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Endpoint summary
Administrative data
Description of key information
Read-across to ESBO (EC No. 232-391-0): LD50 >5000mg/kg bw (equivalent or similar to OECD 401)
Read-across to ESBO (EC No. 232-391-0): LD50 >20 mL/kg bw (equivalent or similar to OECD 402)
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 5 000 mg/kg bw
- Quality of whole database:
- The key study was a read-across study from ESBO and is the only study available. It was assigned a Klimisch score of 2.
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Acute toxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 20
- Quality of whole database:
- Two read-across studies from ESBO were available. Both were assigned a Klimisch score of 2.
Additional information
Acute oral toxicity
There is no acute oral toxicity data available for EPO. A read across approach was conducted with an oral toxicity study from ESBO (EC No. 232-391-0).
The read-across oral acute toxicity study (RL2) was conducted according to a guideline that was equivalent or similar to OECD 401. In the study, ESBO was administered to male and female Tif: RAIf (SPF) rats (5/group) at 5000 mg/kg bw in a limit test. There were no mortalities. Mild clinical signs were noted (slight dyspnoea, slightly ruffled fur, slight diarrhoea and a slightly curved body position) on Day 1 with some cases of ruffled fur and curved body position persisting on days 2 to 4. No gross organ changes were noted. The LD50 (male/female) > 5000 mg/kg bw. An LD50 of >5000 mg/kg bw is also predicted for EPO.
The full read-across report justification is attached.
Acute dermal toxicity
There is no acute dermal toxicity data available for EPO. A read across approach was conducted with dermal toxicity studies from ESBO (EC No. 232-391-0).
Two read-across acute dermal toxicity studies are available. The key read-across study (RL2) was conducted according to a guideline equivalent or similar to OECD 402. In this study, groups of young male New Zealand rabbits (4/sex) were dermally exposed (occlusive) to ESBO (undiluted) for 24 hours at a dose of 20 mL/kg bw. Animals then were observed for 13 days. There were no mortalities and no evidence of derm l toxicity in the 4 rabbits treated. The dermal LD50 (males) for ESBO was >20 mL/kg bw. The dermal LD50 (males) for EPO is also predicted to be >20 mL/kg bw.
The supporting read-across study (RL2) was conducted according to a guideline equivalent or similar to OECD 402. In this study, groups of rabbits were dermally exposed to ESBO at a dose of 20 mL/kg bw. The dermal LD50 for ESBO was >20 mL/kg bw. The dermal LD50 for EPO is also predicted to be >20 mL/kg bw.
The full read-across report justification is attached.
Justification for selection of acute toxicity – oral endpoint
Only one read-across study was available.
Justification for selection of acute toxicity – dermal endpoint
Two read-across studies from ESBO were available. The key study was chosen as it contained the most information.
Justification for classification or non-classification
Based on the available information in the dossier, the substance EPO (CAS No. 1006899‐79‐1) does not need to be classified for acute toxicity or STOT-SE when the criteria outlined in Annex I of 1272/2008/EC are applied, based on the results of the read-across study from ESBO.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.

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