Registration Dossier
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EC number: 810-533-8 | CAS number: 330459-31-9
Long-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
Under the study conditions, NOEC and LOEC values for the test substance were 5.9 and 14 μg a.i./L, respectively. EC50 value for adult immobility was 8.4 μg a.i./L and the EC50 value for reproduction was greater than 14 μg a.i./L, the highest mean, measured concentration tested.
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 0.006 mg/L
Additional information
A study was conducted to determine the effect of the test substance on the survival, growth and reproduction of the cladoceran,Daphnia magna, during a 21 d exposure period under flow-through test conditions, according to ASTM Standard E-1193-97, OECD guideline 211, OPPTS 850.1300, in compliance with GLP.Daphnids were exposed to a geometric series of five test concentrations, 0.38, 0.96, 2.4, 6.0 and 15 μg a.i./L (mean, measured concentrations of 0.35, 0.91, 2.3, 5.9 and 14 μg a.i./L). Two replicate test chambers were tested for each treatment and control group. Each replicate contained two compartments with five daphnids, resulting in a total of 20 daphnids in each treatment and control group.After 21 d of exposure, survival in the 14 μg a.i./L treatment group was statistically significant in comparison to the pooled controls (p ≤ 0.05). Daphnids in the all treatment groups that survived to test termination generally appeared normal, with the exception of one discoloured (pale) Daphnid noted in the 2.3 μg a.i./L treatment group. During the test, lethargic and/or discoloration (pale or orange in colour) were also noted in daphnids in the 2.3, 5.9 and 14 μg a.i./L treatment groups. There were no statistically significant treatment-related effects on reproduction or growth at concentrations ≤5.9 μg a.i./L.
Under the study conditions, NOEC and LOEC values for the test substance were 5.9 and 14 μg a.i./L, respectively. EC50 value for adult immobility was 8.4 μg a.i./L and the EC50 value for reproduction was >14 μg a.i./L. The maximum acceptable toxicant concentration (MATC) value was 9.1 μg a.i./L (Minderhout T, 2014).
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