Registration Dossier
Registration Dossier
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 261-665-2 | CAS number: 59219-71-5
Long-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
No effects up to the limit of water solubility (1.5-4.4 µg/L at 20 °C, OECD 211), read across.
Key value for chemical safety assessment
Additional information
Since no studies investigating the chronic toxicity of 3,5,5-trimethylhexyl 3,5,5-trimethylhexanoate (CAS 59219-71-5) towards aquatic invertebrates are available, in accordance to Regulation (EC) No 1907/2006 Annex XI, 1.5 a read across to the structurally related analogue substance of branched-nonyl 3,5,5 trimethylhexanoate (EC 701-133-3) was conducted. This read across is justified, as both source and target substances are characterized by equal fatty acid moieties ( 3,5,5 trimethylhexanoic acid) and/or similar alcohol moieties (C9 iso alcohol with varying branching options). The read-across is justified in more detail within the analogue justification in IUCLID Section 13. In this case of read-across, the best suited (highest degree of structural similarity, nearest physico-chemical properties) read-across substance was used for the assessment.
One GLP study according to OECD 211 is available investigating the long-term effects of branched-nonyl 3,5,5 trimethylhexanoate (EC 701-133-3) on reproduction, mobility and growth of Daphnia magna (IME, 2013). A water accommodated fraction of the test item at the nominal loading of 100 mg/L was tested under semi-static conditions for 21 d. No effects on the reproduction , mobility and growth of D. magna was observed after the exposure resulting in a NOELR (21 d) ≥ 100 mg/L. Based on this result it can be concluded that no toxicological long-term effects on aquatic invertebrates are expected up to the limit of water solubility for branched-nonyl 3,5,5 trimethylhexanoate.
Based on the results from the structurally related source substance ( branched-nonyl 3,5,5 trimethylhexanoate (EC 701-133-3)) it can be concluded that 3,5,5-trimethylhexyl 3,5,5-trimethylhexanoate (CAS 59219-71-5) does not pose a hazard to aquatic invertebrates under chronic exposure conditions.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
