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Long-term toxicity to aquatic invertebrates

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Description of key information

No effects up to the limit of water solubility (1.5-4.4 µg/L at 20 °C, OECD 211), read across.       

Key value for chemical safety assessment

Additional information

Since no studies investigating the chronic toxicity of 3,5,5-trimethylhexyl 3,5,5-trimethylhexanoate (CAS 59219-71-5) towards aquatic invertebrates are available, in accordance to Regulation (EC) No 1907/2006 Annex XI, 1.5 a read across to the structurally related analogue substance of branched-nonyl 3,5,5 trimethylhexanoate (EC 701-133-3) was conducted. This read across is justified, as both source and target substances are characterized by equal fatty acid moieties ( 3,5,5 trimethylhexanoic acid) and/or similar alcohol moieties (C9 iso alcohol with varying branching options). The read-across is justified in more detail within the analogue justification in IUCLID Section 13. In this case of read-across, the best suited (highest degree of structural similarity, nearest physico-chemical properties) read-across substance was used for the assessment.

One GLP study according to OECD 211 is available investigating the long-term effects of branched-nonyl 3,5,5 trimethylhexanoate (EC 701-133-3) on reproduction, mobility and growth of Daphnia magna (IME, 2013). A water accommodated fraction of the test item at the nominal loading of 100 mg/L was tested under semi-static conditions for 21 d. No effects on the reproduction , mobility and growth of D. magna was observed after the exposure resulting in a NOELR (21 d) ≥ 100 mg/L. Based on this result it can be concluded that no toxicological long-term effects on aquatic invertebrates are expected up to the limit of water solubility for branched-nonyl 3,5,5 trimethylhexanoate.

Based on the results from the structurally related source substance ( branched-nonyl 3,5,5 trimethylhexanoate (EC 701-133-3)) it can be concluded that 3,5,5-trimethylhexyl 3,5,5-trimethylhexanoate (CAS 59219-71-5) does not pose a hazard to aquatic invertebrates under chronic exposure conditions.