Sucrose, glycerol and propane-1,2-diol, reaction products with C16-18(even numbered) fatty acids

Short-term toxicity to aquatic invertebrates

Description of key information

The toxicity of the source substance Sucroglyceride C12-18, C18unsatd. in this read-across approach was investigated in a study conducted according to OECD Guideline 202 I (Daphnia sp. Acute Immobilisation Test). In this test Daphnia magna were exposed to a nominal test substance concentrations of 10, 18, 32, 58, 100 and 180 mg/L over a period of 48 h under static conditions. The study is considered reliable with restrictions as no analytical controls were performed. The 48 h-NOEC based on immobilization was determined to be 18 mg/L. The 48 h-EC50 was 28.5 mg/L (C.I. 26.4 to 30.8 mg/L).

Key value for chemical safety assessment

Fresh water invertebrates

Fresh water invertebrates

Effect concentration:

28.5 mg/L

Additional information

Since no studies investigating the short-term toxicity of Sucrose, glycerol and propane-1,2-diol, reaction products with C16-18(even numbered) fatty acids, to aquatic invertebrates are available, in accordance to Regulation (EC) No 1907/2006 Annex XI, 1.5 a read-across to the structurally related source substance Sucrose and glycerol, reaction products with C12-18, C18unsatd. fatty acids (List No. 938-754-6) was conducted. The read-across substance is representative to evaluate the short-term toxicity of Sucrose, glycerol and propane-1,2-diol, reaction products with C16-18(even numbered) fatty acids (target substance) to aquatic invertebrates.
The target substance is a UVCB substance specified by the reaction product of mainly C16 and C18 linear fatty acids with sucrose, glycerol and propane-1,2-diol. The source substance Sucrose and glycerol, reaction products with C12-18, C18unsatd. fatty acids (List No. 938-754-6) is an UVCB substance resulting by the reaction of a fatty acid mixture with glycerol and sucrose. A detailed analogue approach justification is provided in the technical dossier (see IUCLID Section 13). The source substance has a similar structure and is suitable for read across to the target substance. In this case of read-across, the best suited (highest degree of structural similarity, nearest physico-chemical properties) read-across substance was used for the assessment.
This read-across is justified in detail in the overall summary (IUCLID Section 6.1) and within the analogue justification in IUCLID Section 13.

The toxicity of the source substance Sucroglyceride C12-18, C18unsatd. was investigated in a study conducted according to OECD Guideline 202 I (Daphnia sp. Acute Immobilisation Test), adopted April 4, 1984. In this test Daphnia magna were exposed to nominal test substance concentrations of 10; 18; 32; 58; 100; 180 mg/L over a period of 48 h under static conditions. No analytical controls were performed.

The concentration with no effect (NOEC) based on immobilization was determined to be 18 mg/L after 48 h of exposure.

The study is regarded as reliable, the validity criteria were fulfilled:

- in the control not more that 10% of the daphnids were immobilised;

- the dissolved oxygen concentration at the end of the test was > 3 mg/L in control and test vessels

Synopsis

Test organism/age: Daphnia magna/ <24 h

Test type: static

48 h NOEC: 18 mg/L

48 h EC 50: 28.5 mg/L                     95% C.I. : {26.4 to 30.8 mg/L}

Endpoint affected: mobility