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Physical & Chemical properties

Particle size distribution (Granulometry)

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Endpoint:
particle size distribution (granulometry)
Data waiving:
study scientifically not necessary / other information available
Justification for data waiving:
the study does not need to be conducted because the substance is marketed or used in a non solid or granular form
Endpoint:
particle size distribution (granulometry)
Type of information:
experimental study
Adequacy of study:
key study
Study period:
From October 2, 2009 to November 5, 2009
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to guideline
Guideline:
OECD Guideline 110 (Particle Size Distribution / Fibre Length and Diameter Distributions)
Deviations:
not specified
GLP compliance:
yes (incl. QA statement)
Type of method:
determination of fibre length and diameter distributions
Key result
Percentile:
D50
Remarks on result:
other: Migrated from fields under 'Mass median diameter' as D50 percentile. No source field for Standard deviation.

The test substance was deliquescent (data from melting/freezing point), but it did not liquefy during the test. This ready absorption of atmospheric moisture would further reduce the potential for the test substance to become airborne.

Conclusions:
Under the study conditions the test substance was non-inhalable.
Executive summary:

A study was conducted to determine the particle size distribution of the solid form of test substance according to OECD Guideline 110 (Particle Size Distribution / Fiber Length and Diameter Distributions), in compliance with GLP. A screening test was performed with the test substance (19.71 g) being sieved for approximately 30 min on an Inclyno sieve shaker using a 100 µm sieve. The mass of the test substance that passed through the sieve was 1.28 g. The proportion of the test substance having an inhalable particle size < 100 µm was 6.49%. Under the study conditions the test substance was non-inhalable (Fox, 2009).

 

Description of key information

Solid form: the particle size distribution was determined according to OECD Guideline 110.

Additional information

Solid form: The proportion of the test substance having an inhalable particle size < 100 µm was 6.49%. The test substance was non-inhalable.

Brine: the study does not need to be conducted because the substance is marketed or used in a non-solid or granular form