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EC number: 222-492-8 | CAS number: 3495-36-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Hydrolysis
Administrative data
Link to relevant study record(s)
- Endpoint:
- hydrolysis
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1998
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Remarks:
- A) The study was conducted according to OECD Guideline 111. B) Well-defined information were provided on: 1. Compositional information of the test substance 2. Test methods used in the study 3. Description of methodologies 4. Test results 5. Definite conclusion
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 111 (Hydrolysis as a Function of pH)
- Deviations:
- no
- GLP compliance:
- not specified
- Analytical monitoring:
- yes
- Details on sampling:
- - Sampling intervals for the parent/transformation products: All samples from control at 5°C, control at 50°C and buffer solutions were analysed for total Formate concentration after 5 days.
- Sampling method: No details available
- Sampling methods for the volatile compounds, if any: Not applicable
- Sampling intervals/times for pH measurements: No data on pH measurements
- Sampling intervals/times for sterility check: Not applicable
- Sample storage conditions before analysis: Samples were immediately analysed after the test period of 5 days.
- Other observation, if any (e.g.: precipitation, color change etc.): None - Buffers:
- - pH: 4.0
- Type and final molarity of buffer: No data
- Composition of buffer: 2 mL of 0.1 N NaOH and 250 mL of 0.1 M Potassium Biphthalate were mixed and diluted to 500 mL with sterilised deionised water
- pH: 7.0
- Type and final molarity of buffer: No data
- Composition of buffer: 148.2 mL of 0.1 N NaOH and 250 mL of 0.1 M Monopotassium Phosphate were mixed and diluted to 500 mL with sterilised deionised water
- pH: 9.0
- Type and final molarity of buffer: No data
- Composition of buffer: 106.5 mL of 0.1 N NaOH and 250 mL of 0.1 M H3BO3 in 0.1 M KCl were mixed and diluted to 500 mL with sterilised deionised water - Estimation method (if used):
- The pH of the buffer solution is estimated by pH meter
- Details on test conditions:
- TEST SYSTEM
- Type, material and volume of test flasks, other equipment used: 100 mL glass volumetric flasks containing 100 mL of the test solution
- Sterilisation method: Autoclaving
- Measures taken to avoid photolytic effects: The water bath was housed in black plastic covered fume hood to avoid photolytic reaction
- Measures to exclude oxygen: All the flasks were sparged with nitrogen gas for 2 min - Duration:
- 5 d
- pH:
- 4
- Initial conc. measured:
- ca. 0.008 mol/L
- Duration:
- 5 d
- pH:
- 7
- Initial conc. measured:
- ca. 0.008 mol/L
- Duration:
- 5 d
- pH:
- 9
- Initial conc. measured:
- ca. 0.008 mol/L
- Duration:
- 5 d
- Temp.:
- 5 °C
- Initial conc. measured:
- 0.008 mol/L
- Duration:
- 5 d
- Initial conc. measured:
- ca. 0.008 mol/L
- Number of replicates:
- Duplicate
- Positive controls:
- yes
- Remarks:
- Flasks (in duplicate) containing test solution diluted with deionised water without buffer were kept at 5°C and 50°C for 5 d
- Negative controls:
- no
- Preliminary study:
- The mean final concentration of the test substance solution in the control was 0.0086 M, in the blank test substance solution without buffer at 50 °C was 0.0083 M, and in all three buffered test solutions (pH 4.0, 7.0 and 9.0) was 0.0084 M.
- Test performance:
- The Formate concentrations in the buffered test solutions at 50 °C were very close to the initially added. The relative differences in the Formate concentrations between the buffered test solutions and the control at 5 °C were less than 3%.
- Transformation products:
- not specified
- Details on hydrolysis and appearance of transformation product(s):
- Not applicable
- % Recovery:
- ca. 97
- pH:
- 4
- Temp.:
- 50 °C
- Duration:
- ca. 5 d
- % Recovery:
- ca. 97
- pH:
- 7
- Temp.:
- 50 °C
- Duration:
- ca. 5 d
- % Recovery:
- ca. 97
- pH:
- 9
- Temp.:
- 50 °C
- Duration:
- ca. 5 d
- Key result
- Remarks on result:
- hydrolytically stable based on preliminary test
- Details on results:
- The Formate concentrations in the buffered test solutions at 50°C were very close to that initially added. The relative differences in the Formate concentrations between the buffered test solutions and the control at 5°C were less than 3%.
- Validity criteria fulfilled:
- not specified
- Remarks:
- 1. Duplicate buffered test solutions were used. 2. Recovery of test material was within recommended range (90-110 %).
- Conclusions:
- Under the study conditions the test substance solution was considered to be hydrolytically stable.
- Executive summary:
A study was conducted to determine the hydrolytic stability of the test substance solution according to OECD Guideline 111. 0.1 M of the test substance solution was mixed with pH 4.0, 7.0 and 9.0 buffered solutions in duplicate 100 mL volumetric flasks and kept in a light-protected water bath at 50±0.1°C for 5 days. Concurrent controls without buffers were also kept at 50±0.1°C and 5°C for 5 days. All samples were analysed in HPLC for total formate concentration immediately after removal from water bath. The relative differences in the formate concentrations between the buffer pH solutions and the control at 5°C were less than 3%. Under the study conditions the test substance solution was considered to be hydrolytically stable (Gibb, 1998).
Reference
Table 1. Final concentrations of Formate in the controls and buffered test solutions after 5 days
Test Condition | Final concentration | Final concentration | Relative to Control at 5°C | |
(M) | (M) | % | ||
Control | 5°C | 0.0084 | 0.0086 | - |
0.0087 | ||||
Control | 50°C | 0.0082 | 0.0083 | -3.5 |
0.0084 | ||||
Buffer pH 4.0 | 50 °C | 0.0085 | 0.0084 | -2.3 |
0.0083 | ||||
Buffer pH 7.0 | 50°C | 0.0083 | 0.0084 | -2.3 |
0.0085 | ||||
Buffer pH 9.0 | 50 °C | 0.0084 | 0.0084 | -2.3 |
0.0084 |
Description of key information
Key value for chemical safety assessment
Additional information
A study was conducted to determine the hydrolytic stability of the test substance solution according to OECD Guideline 111. 0.1 M of the test substance solution was mixed with pH 4.0, 7.0 and 9.0 buffered solutions in duplicate 100 mL volumetric flasks and kept in a light-protected water bath at 50±0.1°C for 5 days. Concurrent controls without buffers were also kept at 50±0.1°C and 5°C for 5 days. All samples were analysed in HPLC for total formate concentration immediately after removal from water bath. The relative differences in the formate concentrations between the buffer pH solutions and the control at 5°C were less than 3%. Under the study conditions the test substance solution was considered to be hydrolytically stable (Gibb, 1998).
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