Registration Dossier
Registration Dossier
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The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
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EC number: 201-377-6 | CAS number: 81-81-2
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation / corrosion
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
Data source
Referenceopen allclose all
- Reference Type:
- review article or handbook
- Title:
- Unnamed
- Year:
- 2 009
- Report date:
- 2009
- Reference Type:
- secondary source
- Title:
- Warfarin-induced necrosis of the skin
- Author:
- DeFranzo AJ, Marasco P, Argenta LC
- Year:
- 1 995
- Bibliographic source:
- Ann. Plast. Surg. 34, 203-208
- Reference Type:
- secondary source
- Title:
- Unnamed
- Year:
- 1 994
Materials and methods
- Principles of method if other than guideline:
- Method data are not available as the report details are unpublished.
- GLP compliance:
- yes
- Remarks:
- 1994 is & 1995 is not GLP
Test material
- Reference substance name:
- Warfarin
- EC Number:
- 201-377-6
- EC Name:
- Warfarin
- Cas Number:
- 81-81-2
- Molecular formula:
- C19H16O4
- IUPAC Name:
- 4-hydroxy-3-(3-oxo-1-phenylbutyl)-2H-chromen-2-one
Constituent 1
Test animals
- Species:
- rabbit
Test system
- Type of coverage:
- semiocclusive
- Duration of treatment / exposure:
- 4 hour
Results and discussion
In vivo
Results
- Irritation parameter:
- overall irritation score
- Time point:
- other: 4 hour
- Remarks on result:
- other: non -irritant
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
