Registration Dossier
Registration Dossier
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EC number: 203-105-1 | CAS number: 103-37-7
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- Data is from peer reviewed journal
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Acute dermal toxicity of test chemical in rabbits
- Author:
- D. Belsito et. al.
- Year:
- 2 012
- Bibliographic source:
- Food and Chemical Toxicology ,2012
- Reference Type:
- other: authoritative database
- Title:
- Acute dermal toxicity of test chemical in rabbits
- Author:
- U.S. National Library of Medicine
- Year:
- 2 018
- Bibliographic source:
- Chemidplus Database,U.S. National Library of Medicine,2018
- Reference Type:
- publication
- Title:
- Acute dermal toxicity of test chemical in rabbits
- Author:
- D. L. J. Opdyke
- Year:
- 1 974
- Bibliographic source:
- Food and Cosmetics Toxicology,1974
- Reference Type:
- publication
- Title:
- Acute dermal toxicity of test chemical in rabbits
- Author:
- D. McGinty et. al.
- Year:
- 2 012
- Bibliographic source:
- Food and Chemical Toxicology,2012
- Reference Type:
- other: secondary source
- Title:
- Acute dermal toxicity of test chemical in rabbits
- Author:
- RTECS
- Year:
- 2 018
- Bibliographic source:
- RTECS (registry of toxic effect of chemical substance database), 2018
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: As mentioned below
- Principles of method if other than guideline:
- Acute dermal toxicity study of test chemical was performed in rabbits.
- GLP compliance:
- not specified
- Test type:
- other: not specified
- Limit test:
- no
Test material
- Reference substance name:
- Benzyl butyrate
- EC Number:
- 203-105-1
- EC Name:
- Benzyl butyrate
- Cas Number:
- 103-37-7
- Molecular formula:
- C11H14O2
- IUPAC Name:
- benzyl butanoate
- Test material form:
- liquid
- Details on test material:
- - Name of test material (as cited in study report): Benzyl butyrate
- IUPAC NAME: Butanoic acid, phenylmethyl ester
- Molecular formula : C11H14O2
- Molecular weight : 178.23 g/mole
- Smiles notation : c1(COC(CCC)=O)ccccc1
- InChl : 1S/C11H14O2/c1-2-6-11(12)13-9-10-7-4-3-5-8-10/h3-5,7-8H,2,6,9H2,1H3
- Substance type: Organic
- Physical state: liquid
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- No data available
Administration / exposure
- Type of coverage:
- not specified
- Vehicle:
- not specified
- Details on dermal exposure:
- No data available
- Duration of exposure:
- No data available
- Doses:
- 5000 mg/kg bw
- No. of animals per sex per dose:
- 5 animals
- Control animals:
- not specified
- Details on study design:
- Details on study design
- Duration of observation period following administration: 14 days
- Frequency of observations and weighing: 14 days
- Necropsy of survivors performed: no
- Other examinations performed: clinical signs and mortality
other: No data available - Statistics:
- No data available
Results and discussion
- Preliminary study:
- No data available
Effect levels
- Key result
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: no mortality was observed
- Mortality:
- No mortality was observed in rabbits dosed with 5000 mg/kg bw.
- Clinical signs:
- other: No clinical signs observed
- Gross pathology:
- No data available
- Other findings:
- No data available
Applicant's summary and conclusion
- Interpretation of results:
- other: not classified
- Conclusions:
- The LD50 value was considered to be >5000 mg/kg bw,when five rabbits were treated with test chemical by dermal application following 14 days of observation period.
- Executive summary:
In acute dermal toxicity study, five rabbits were treated with test chemical in the concentration of 5000 mg/kg bw by dermal application followed by a 14 days observation period.No mortality was observed in treated rabbits at dose 5000 mg/kg bw. Necropsy was not conducted. Therefore, LD50 value was considered to be >5000 mg/kg bw,when rabbits were treated with test chemical by dermal application.
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