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Acute Toxicity: dermal

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Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Justification for type of information:
Data is from peer reviewed journal

Data source

Referenceopen allclose all

Reference Type:
publication
Title:
Acute dermal toxicity of test chemical in rabbits
Author:
D. Belsito et. al.
Year:
2012
Bibliographic source:
Food and Chemical Toxicology ,2012
Reference Type:
other: authoritative database
Title:
Acute dermal toxicity of test chemical in rabbits
Author:
U.S. National Library of Medicine
Year:
2018
Bibliographic source:
Chemidplus Database,U.S. National Library of Medicine,2018
Reference Type:
publication
Title:
Acute dermal toxicity of test chemical in rabbits
Author:
D. L. J. Opdyke
Year:
1974
Bibliographic source:
Food and Cosmetics Toxicology,1974
Reference Type:
publication
Title:
Acute dermal toxicity of test chemical in rabbits
Author:
D. McGinty et. al.
Year:
2012
Bibliographic source:
Food and Chemical Toxicology,2012
Reference Type:
other: secondary source
Title:
Acute dermal toxicity of test chemical in rabbits
Author:
RTECS
Year:
2018
Bibliographic source:
RTECS (registry of toxic effect of chemical substance database), 2018

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: As mentioned below
Principles of method if other than guideline:
Acute dermal toxicity study of test chemical was performed in rabbits.
GLP compliance:
not specified
Test type:
other: not specified
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Benzyl butyrate
EC Number:
203-105-1
EC Name:
Benzyl butyrate
Cas Number:
103-37-7
Molecular formula:
C11H14O2
IUPAC Name:
benzyl butanoate
Test material form:
liquid
Details on test material:
- Name of test material (as cited in study report): Benzyl butyrate
- IUPAC NAME: Butanoic acid, phenylmethyl ester
- Molecular formula : C11H14O2
- Molecular weight : 178.23 g/mole
- Smiles notation : c1(COC(CCC)=O)ccccc1
- InChl : 1S/C11H14O2/c1-2-6-11(12)13-9-10-7-4-3-5-8-10/h3-5,7-8H,2,6,9H2,1H3
- Substance type: Organic
- Physical state: liquid

Test animals

Species:
rabbit
Strain:
not specified
Sex:
not specified
Details on test animals or test system and environmental conditions:
No data available

Administration / exposure

Type of coverage:
not specified
Vehicle:
not specified
Details on dermal exposure:
No data available
Duration of exposure:
No data available
Doses:
5000 mg/kg bw
No. of animals per sex per dose:
5 animals
Control animals:
not specified
Details on study design:
Details on study design
- Duration of observation period following administration: 14 days
- Frequency of observations and weighing: 14 days
- Necropsy of survivors performed: no
- Other examinations performed: clinical signs and mortality
other: No data available
Statistics:
No data available

Results and discussion

Preliminary study:
No data available
Effect levels
Key result
Sex:
not specified
Dose descriptor:
LD50
Effect level:
> 5 000 mg/kg bw
Based on:
test mat.
Remarks on result:
other: no mortality was observed
Mortality:
No mortality was observed in rabbits dosed with 5000 mg/kg bw.
Clinical signs:
other: No clinical signs observed
Gross pathology:
No data available
Other findings:
No data available

Applicant's summary and conclusion

Interpretation of results:
other: not classified
Conclusions:
The LD50 value was considered to be >5000 mg/kg bw,when five rabbits were treated with test chemical by dermal application following 14 days of observation period.
Executive summary:

In acute dermal toxicity study, five rabbits were treated with test chemical in the concentration of 5000 mg/kg bw by dermal application followed by a 14 days observation period.No mortality was observed in treated rabbits at dose 5000 mg/kg bw. Necropsy was not conducted. Therefore, LD50 value was considered to be >5000 mg/kg bw,when rabbits were treated with test chemical by dermal application. 

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