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Short-term toxicity to aquatic invertebrates

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Description of key information

The effective concentration (EC50) values of 1,3-isobenzofurandione, reaction products with methylquinoline and quinoline (D & C Yellow No. 11) based on the effect of mortality in aquatic invertebrate (Daphnia magna)  in a 48 hrs study was found to be >0.17mg/L and No mortality observed at 0.17mg/L.

The other weight of evidence studies also indicate the EC50 values to be in the range more than 0.17-0.18 mg/L.  Thus, considering only the EC50 values, the studies indicate Aquatic toxicity since though the EC50 values are in the classifying, as the range is not specified. Considering the weight of evidence results 1,3-isobenzofurandione, reaction products with methylquinoline and quinoline (D & C Yellow No. 11) is not classified.

Key value for chemical safety assessment

Additional information

No. of studies were reviewed for Short-term toxicity to aquatic invertebrate from reliable sources having Klimish rating 2.

The summary of the results are presented below:

Sr. No.

Endpoint name

Duration

Value

Units

Species

Source

1.     

EC50

48 hr

>0.17

mg/L

Daphnia magna

Data from publication for CAS: 8003-22-3

2.     

EC50

48 hr

>0.17

mg/L

Midge larva

Data from publication for CAS: 8003-22-3

3.     

EC50

48 hr

>0.18

mg/L

Mayfly larva

Data from publication for CAS: 8003-22-3

 

No mortality observed at any values indicated in above table alsoas the range is not specifiedThe substance 1,3-isobenzofurandione, reaction products with methylquinoline and quinoline (D & C Yellow No. 11) will not exhibit aquatic toxicity to aquatic invertebrate.