Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 943-366-5 | CAS number: -
Endpoint summary
Administrative data
Description of key information
Additional information
The target substance is an UVCB substance consisting of adipic acid, di-anhydride with bis(acetic acid) (ca. 57 %), Acetic acid (ca.32.5 %), acetic anhydride (ca. 7.1 %), adipic anhydride (ca. 1.5 %) and oligomeric adipic anhydrides (ca. 1.0 %).
Acetic anhydride is unstable in water and decomposes immediately (half-life about 4 minutes) in contact with water to acetic acid/acetate. Adipic anhydrides hydrolyse also rapidly when in contact with water to adipic acid and acetic acid. Therefore, the assessment of aquatic toxicity is based on read-across data from the most hazardous constituent and hydrolysis products.
All of the constituents of the target substance are not classified hazardous for the environment. The main effect for the environment from the target substance is the lowering of pH after hydrolysis of the acetic anhydride and formation of acetic acid.
Short-term toxicity to fish:
Lowest 72 -h LC50 value for freshwater: 97 mg/l (read-across from adipic acid, Mattson et al. 1976).
Lowest 48-h LC50 value for saltwater (48 -h LC50): 350 mg/l (read-across from Acetic acid, Onitsuka et al. 1989).Short term and long-term toxicity to invertebrates:
Short-term toxicity to invertebrates:
Lowest value for freshwater (Daphnia magna) 24-h LC50: 55 mg/L (read-across from acetic anhydride, Bringmann & Kuhn 1982).
No data for sea water.
Toxicity to algae:
Lowest 7-d EC50 for freshwater is 279 mg/l (read-across from adipic acid, Sepi et al. 2003).
Lowest LOEC for freshwater: 90 mg/l (Read-across from acetic acid. Bringmann & Kuhn 1978)
Toxicity to microorganisms:
Lowest 16-h NOEC: 850 mg/ml (read-across acetic acid, Bringmann & Kuhn 1982).
Lowest 40-h EC50: 36 mg/l (read-across from adipic acid, Bringmann & Kuhn 1980).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
