Registration Dossier
Registration Dossier
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EC number: 204-504-3 | CAS number: 121-89-1
Endpoint summary
Administrative data
Description of key information
Bioaccumulation: aquatic / sediment:
Based on an experimental log/octanol water partition coefficient of 1.42, a bioconcentration factor of 7.1 (dimensionless)can be calculated for 3'-nitroacetophenone (i.e m-nitroacetophenone) using an appropriate regression equation. This value indicates that 3'-nitroacetophenone will not bioconcentrate in fish and aquatic organisms.
Additional information
Bioaccumulation: aquatic / sediment:
Four studies including experimental and predicted report from validated models for Bioaccumulation endpoint for the target chemical 3'-nitroacetophenone (Cas no. 121-89-1) were reviewed to summarize as follows:
First report is from authorative database (HSDB database; 2017) for target chemical 3'-nitroacetophenone, which suggest that based on an experimental log octanol water partition coefficient of 1.42, a bioconcentration factor of 7.1 (dimensionless) can be calculated for 3'-nitroacetophenone (i.e m-nitroacetophenone) using an appropriate regression equation. This value indicates that 3'-nitroacetophenone will not bioconcentrate in fish and aquatic organisms.
Above experimental study supported by another predicted report of EPI suite using BCFBAF Program (v3.01) model which indicate the Bioaccumulation factor (BCF) was predicted to be 1.044 L/kg wet-wt at 25 deg.C for target chemical3'-nitroacetophenone.The predicted BCF value does not exceed the bioconcentration threshold of 2000.Thus it is concluded that 3'-nitroacetophenone is not expected to bio accumulate in the food chain.
Another predicted database i.e PBT profiler indicate the Bioaccumulation factor (BCF) was predicted to be 1 L/kg wet-wt at 25 deg.C. Based on the BCF concentration it is concluded that the test chemical 3'-nitroacetophenone is non bioaccumulative in nature as it does not exceed the BCF criteria of 2000.
Last evidence from Scifinder database suggest the Bioconcentration factor (BCF) for target chemical 3'-nitroacetophenone was predicted to be 7.07 at pH 1-10 and temperature 25 deg.C.Based on the BCF concentration it is concluded that the test chemical 3'-nitroacetophenone is non bioaccumulative in nature as it does not exceed the BCF criteria of 2000.
All experimental and predicted data source gives BCF value in the range of 1-7.1 (L/kg wet-wt or dimensionless), Thus based on the available BCF range concluded that the target chemical 3'-nitroacetophenone (Cas no. 121-89-1) is non Bioaccumulative in aquatic environment.
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