Registration Dossier
Registration Dossier
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 460-110-3 | CAS number: 797751-43-0 WASOX-MMAC2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Adsorption / desorption
Administrative data
Link to relevant study record(s)
- Endpoint:
- adsorption / desorption: screening
- Data waiving:
- study technically not feasible
- Justification for data waiving:
- other:
- Justification for type of information:
- JUSTIFICATION FOR DATA WAIVING
The study is technically not feasible since the substance is hydrolytically unstable (half-life < 1h). - Endpoint:
- adsorption / desorption: screening
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Remarks:
- According to OECD Guideline 121.
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 121 (Estimation of the Adsorption Coefficient (Koc) on Soil and on Sewage Sludge using High Performance Liquid Chromatography (HPLC))
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.19 (Estimation of the Adsorption Coefficient (KOC) on Soil and Sewage Sludge Using High Performance Liquid Chromatography (HPLC))
- Type of method:
- HPLC estimation method
- Validity criteria fulfilled:
- not applicable
- Conclusions:
- The adsorption coefficient Koc of test item Wasox-MMAC2 using HPLC could not be determined due to rapid hydrolysis (half-life < 1h) of the substance.
- Executive summary:
An experimental determination of adsorption coefficient Koc of test item Wasox-MMAC2 using HPLC could not be performed, because 1) the test substance rapidly degrades with a half-life time of <1 hour at 25°C, and 2) the test substance is a mixture of several compounds and reacts with water as part of the eluent.
- Endpoint:
- adsorption / desorption, other
- Type of information:
- (Q)SAR
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification
- Remarks:
- Internationally accepted method, EPI-Suite, EPA (USA)
- Justification for type of information:
- See attached the QMRF and QPRF for the QSAR model.
- Guideline:
- other: REACH Guidance on QSARs R.6
- Principles of method if other than guideline:
- Meylan, W., P.H. Howard and R.S. Boethling, "Molecular Topology/Fragment Contribution Method for Predicting Soil Sorption Coefficients", Environ. Sci. Technol. 26: 1560-7 (1992).
SRC.1991. Group Contribution Method for Predicting Soil Sorption Coefficients. William Meylan & Philip H. Howard, Syracuse Research Corporation (June 3, 1991). EPA Contract No. 68-D8-0117 (Work Assignment 2-19); SRC F0118-219. - Type:
- Koc
- Value:
- 60.7 L/kg
- Remarks on result:
- other: QSAR predicted value (KOCWIM v2.00, MCI method, no data on temperature and organic carbon is provided)
- Type:
- log Koc
- Value:
- 1.783 dimensionless
- Remarks on result:
- other: QSAR predicted value (KOWMIN v2.00, MCI method, no data on temperature and organic carbon is provided)
- Validity criteria fulfilled:
- not applicable
- Conclusions:
- The estimated soil adsorption coefficients Koc and Log Koc (KOCWIN v2.00, MCI method) of acetone oxime is 60.7 and 1.783 respectively.
- Executive summary:
The estimated soil adsorption coefficients Koc and Log Koc (KOCWIN v2.00, MCI method) of acetone oxime is 60.7 and 1.783 respectively.
- Endpoint:
- adsorption / desorption, other
- Type of information:
- (Q)SAR
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification
- Remarks:
- Internationally accepted method, EPI-Suite, EPA (USA)
- Justification for type of information:
- See attached the QMRF and QPRF for the QSAR model.
- Guideline:
- other: REACH Guidance on QSARs R.6
- Principles of method if other than guideline:
- Meylan, W., P.H. Howard and R.S. Boethling, "Molecular Topology/Fragment Contribution Method for Predicting Soil Sorption Coefficients", Environ. Sci. Technol. 26: 1560-7 (1992).
SRC.1991. Group Contribution Method for Predicting Soil Sorption Coefficients. William Meylan & Philip H. Howard, Syracuse Research Corporation (June 3, 1991). EPA Contract No. 68-D8-0117 (Work Assignment 2-19); SRC F0118-219. - Specific details on test material used for the study:
- SMILES: CO[Si](C)(O)OC
- Type:
- Koc
- Value:
- 168.6 L/kg
- Remarks on result:
- other: QSAR predicted value (KOCWIM v2.00, MCI method, no data on temperature and organic carbon is provided)
- Type:
- log Koc
- Value:
- 2.227 dimensionless
- Remarks on result:
- other: QSAR predicted value (KOWMIN v2.00, MCI method, no data on temperature and organic carbon is provided)
- Validity criteria fulfilled:
- not applicable
- Conclusions:
- The estimated soil adsorption coefficients Koc and Log Koc (KOCWIN v2.00, MCI method) of dimethoxymethylsilanol is 168.6 and 2.227 respectively.
- Executive summary:
The estimated soil adsorption coefficients Koc and Log Koc (KOCWIN v2.00, MCI method) of dimethoxymethylsilanol is 168.6 and 2.227 respectively.
- Endpoint:
- adsorption / desorption, other
- Type of information:
- (Q)SAR
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification
- Remarks:
- Internationally accepted method, EPI-Suite, EPA (USA)
- Justification for type of information:
- See attached the QMRF and QPRF for the QSAR model.
- Guideline:
- other: REACH Guidance on QSARs R.6
- Principles of method if other than guideline:
- Meylan, W., P.H. Howard and R.S. Boethling, "Molecular Topology/Fragment Contribution Method for Predicting Soil Sorption Coefficients", Environ. Sci. Technol. 26: 1560-7 (1992).
SRC.1991. Group Contribution Method for Predicting Soil Sorption Coefficients. William Meylan & Philip H. Howard, Syracuse Research Corporation (June 3, 1991). EPA Contract No. 68-D8-0117 (Work Assignment 2-19); SRC F0118-219. - Specific details on test material used for the study:
- SMILES: CO[Si](C)(O)O
- Type:
- Koc
- Value:
- 86.03 L/kg
- Remarks on result:
- other: QSAR predicted value (KOCWIM v2.00, MCI method, no data on temperature and organic carbon is provided)
- Type:
- log Koc
- Value:
- 1.935 dimensionless
- Remarks on result:
- other: QSAR predicted value (KOWMIN v2.00, MCI method, no data on temperature and organic carbon is provided)
- Validity criteria fulfilled:
- not applicable
- Conclusions:
- The estimated soil adsorption coefficients Koc and Log Koc (KOCWIN v2.00, MCI method) of methoxymethylsilanediol is 86.03 and 1.935 respectively.
- Executive summary:
The estimated soil adsorption coefficients Koc and Log Koc (KOCWIN v2.00, MCI method) of methoxymethylsilanediol is 86.03 and 1.935 respectively.
- Endpoint:
- adsorption / desorption, other
- Type of information:
- (Q)SAR
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification
- Remarks:
- Internationally accepted method, EPI-Suite, EPA (USA)
- Justification for type of information:
- See attached the QMRF and QPRF for the QSAR model.
- Guideline:
- other: REACH Guidance on QSARs R.6
- Principles of method if other than guideline:
- Meylan, W., P.H. Howard and R.S. Boethling, "Molecular Topology/Fragment Contribution Method for Predicting Soil Sorption Coefficients", Environ. Sci. Technol. 26: 1560-7 (1992).
SRC.1991. Group Contribution Method for Predicting Soil Sorption Coefficients. William Meylan & Philip H. Howard, Syracuse Research Corporation (June 3, 1991). EPA Contract No. 68-D8-0117 (Work Assignment 2-19); SRC F0118-219. - Specific details on test material used for the study:
- SMILES: [Si](O)(O)(O)C
- Type:
- Koc
- Value:
- 43.89 L/kg
- Remarks on result:
- other: QSAR predicted value (KOCWIM v2.00, MCI method, no data on temperature and organic carbon is provided)
- Type:
- log Koc
- Value:
- 1.642 dimensionless
- Remarks on result:
- other: QSAR predicted value (KOWMIN v2.00, MCI method, no data on temperature and organic carbon is provided)
- Validity criteria fulfilled:
- not applicable
- Conclusions:
- The estimated soil adsorption coefficients Koc and Log Koc (KOCWIN v2.00, MCI method) of methylsilanetriol is 43.89 and 1.642 respectively.
- Executive summary:
The estimated soil adsorption coefficients Koc and Log Koc (KOCWIN v2.00, MCI method) of methylsilanetriol is 43.89 and 1.642 respectively.
Referenceopen allclose all
An experimental determination of the adsorption coefficient Koc could not be performed, because:
1) the test substance rapidly degrades with a half-life time of <1 hour at 25°C, see separate report on the hydrolysis and,
2) the test substance is a mixture of several compounds and reacts with water as part of the eluent.
Description of key information
The Log Koc and Koc of test item should be understood based on its degradation products since it undergoes rapid hydrolysis (half-life < 1h) in water to acetone oxime (log Kow = 1.783 and Koc = 60.7, KOCWIN v2.00) and silanols (Log Kow in the range of 1.642-2.227 and Koc 43.89-168.6 KOWWIN v1.68). Moreover, it should be pointed out that the corresponding silanols undergo continuous condensation reactions to produce higher molecular weight siloxanes which are considered biologically unavailable. Therefore, the Key value for chemical safety assessment would be the adsorption coefficient of acetone oxime.
Key value for chemical safety assessment
- Koc at 20 °C:
- 60.7
Additional information
Data waiving (study technically not feasible): An experimental determination of adsorption coefficient Koc of test item Wasox-MMAC2 using HPLC could not be performed, because 1) the test substance rapidly degrades with a half-life time of <1 hour at 25°C, and 2) the test substance is a mixture of several compounds and reacts with water as part of the eluent.
It should be also taken into account that the substance undergoes rapid hydrolysis (half-life < 1h) in aqueous to acetone oxime and the corresponding silanols. The estimated partition coefficients log Koc and Koc for the degradation products acetone oxime and silanols were estimated to be in the range of 1.642 -2.227 and 43.89 -168.6 L/kg (EPI-Suite, KOCWIN v2.00) respectively (log Kow < 3, low bioaccumulation for adsorption). Moreover, it should be pointed out that the corresponding silanols undergo continuous condensation reactions to produce higher molecular weight siloxanes which are considered biologically unavailable. Therefore, the Key value for chemical safety assessment would be the adsorption coefficient of acetone oxime, i.e. Koc of 60.7 L/kg and Log Koc of 1.783.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.

EU Privacy Disclaimer
This website uses cookies to ensure you get the best experience on our websites.