Mercury sulphate

Developmental toxicity / teratogenicity

Administrative data

Endpoint:

developmental toxicity

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Data is from peer reviewed journal

Data source

Reference

Reference Type:

publication

Title:

Effects of PCBs, DDT, and Mercury Compounds upon Egg Production, Hatchability and Shell Quality in Chickens and Japanese Quail

Author:

M. L. SCOTT, J. R. ZIMMERMANN, SUSAN MARINSKY AND P. A. MULLENHOFF, G. L. RUMSEY AND R. W. RICE

Year:

1975

Bibliographic source:

Poultry sciences,1975

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

other: as per below

Principles of method if other than guideline:

The developmental study of chicken were studied and chickens was treated for 8 weeks with 100 and 200 mg/kg concentration of mercury sulphate.

GLP compliance:

not specified

Test material

Test material information

Constituent 1

Reference substance name:

Mercury sulphate

EC Number:

231-992-5

EC Name:

Mercury sulphate

Cas Number:

7783-35-9

Molecular formula:

H2O4S.Hg

IUPAC Name:

mercury sulfate

Details on test material:

- Name of test material: Mercury sulphate
- Molecular formula: H2O4S.Hg
- Molecular weight : 298.67 g/mol
- Smiles notation: [O-]S(=O)(=O)[O-].[Hg+2]
- InChl : InChI=1S/Hg.H2O4S/c;1-5(2,3)4/h;(H2,1,2,3,4)/q+2;/p-2
- Substance type: Solid
- Physical state: Inorganic
- Impurities (identity and concentrations): No data

Test animals

Species:

other: Chickens

Strain:

other: White Leghorn

Details on test animals or test system and environmental conditions:

Details on test animal & Environmental conditions

TEST ANIMALS
- Source: No data available
- Age at study initiation: 12-1/2 months of age.
- Weight at study initiation: No data available
- Fasting period before study: No data available
- Housing: No data available
- Diet (e.g. ad libitum): 3.5% calcium Diet A (ad libitum)
- Water (e.g. ad libitum): ad libitum
- Acclimation period: No data available

ENVIRONMENTAL CONDITIONS
- Temperature (°C): No data available
- Humidity (%):No data available
- Air changes (per hr): No data available
- Photoperiod (hrs dark / hrs light): No data available

IN-LIFE DATES: From: To: No data available

Administration / exposure

Route of administration:

oral: feed

Type of inhalation exposure (if applicable):

not specified

Vehicle:

other: Feed

Details on exposure:

No data available

Analytical verification of doses or concentrations:

not specified

Details on analytical verification of doses or concentrations:

No data available

Details on mating procedure:

No data available

Duration of treatment / exposure:

8 weeks

Frequency of treatment:

Daily

Duration of test:

100 and 200 mg/kg

No. of animals per sex per dose:

One hundred and eighty hens housed in individual cages were divided into nine sets of four groups of five hens per group to receive each treatment.

Details on study design:

No data available

Examinations

Maternal examinations:

No data available

Ovaries and uterine content:

No data available

Fetal examinations:

No data available

Statistics:

No data available

Indices:

No data available

Historical control data:

No data available

Results and discussion

Results: maternal animals

Maternal developmental toxicity

Details on maternal toxic effects:

Maternal toxic effects:yes. Remark: Feed intake of the hens, changes in average body weights and percent egg production for each treatment over an 8 week experimental period

Effect levels (maternal animals)

Dose descriptor:

LOAEL

Effect level:

200 mg/kg diet

Based on:

test mat.

Basis for effect level:

other: developmental toxicity

Results (fetuses)

Details on embryotoxic / teratogenic effects:

Embryotoxic / teratogenic effects:yes

Details on embryotoxic / teratogenic effects:
Mercuric sulfate appeared to have only a slight effect upon egg weights, egg size.
Mercuric sulfate had no effect upon the relative distribution of yolk, albumen and shell.
The hatchability of fertile eggs collected during the seventh week was decreased somewhat by the mercuric sulfate.
The decreases in shell quality for the first eggs in the clutch were not severe,
whereas the second eggs showed significant decreases in shell thickness with the dietary treatment of both 200 p.p.m. of mercuric sulfate

Fetal abnormalities

Abnormalities:

not specified

Overall developmental toxicity

Developmental effects observed:

not specified

Applicant's summary and conclusion

Conclusions:

The endpoint of development study for mercury sulphate(7783-35-9) was found to be LOAEL at 200 mg/kg.

Executive summary:

The developmental study of chicken were studied and chickens was treated for 8 weeks with 100 and 200 mg/kg concentration of mercury sulphate. One hundred and eighty hens housed in individual cages were divided into nine sets

of four groups of five hens per group to receive each treatment. Feed and water were supplied ad libitum. The basal diet was the 3.5% calcium Diet A.Egg production was recorded daily, feed intake measured every two weeks, and eggshell

quality determined at biweekly intervals.Feed intake of the hens, changes in average body weights and percent egg production for each treatment over an 8 week experimental period.

Mercuric sulfate appeared to have only a slight effect upon egg weights, egg size. Mercuric sulfate had no effect upon the relative distribution of yolk, albumen and shell. The hatchability of fertile eggs collected during the seventh week was decreased somewhat by the mercuric sulfate.The decreases in shell quality for the first eggs in the clutch were not severe,whereas the second eggs showed significant decreases in shell thickness with the dietary treatment of both 200mg/kg of mercuric sulfate.

Therefore, theendpoint of development study for mercury sulphate (7783-35-9) was found to be LOAEL at 200 mg/kg.