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Registration Dossier
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EC number: 201-846-5 | CAS number: 88-63-1
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Data is from authorative handbook
Data source
Reference
- Reference Type:
- review article or handbook
- Title:
- Evaluate irritation effect of 1,3-Phenylenediamine-4-sulfonic acid on rabbit skin
- Author:
- Richard J. Lewis, Sr.
- Year:
- 2 012
- Bibliographic source:
- Sax’s Dangerous Properties of Industrial Materials, 12th Edition
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: as mentioned below
- Principles of method if other than guideline:
- Evaluate irritation effect of 1,3-Phenylenediamine-4-sulfonic acid on rabbit skin.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 2,4-diaminobenzenesulphonic acid
- EC Number:
- 201-846-5
- EC Name:
- 2,4-diaminobenzenesulphonic acid
- Cas Number:
- 88-63-1
- Molecular formula:
- C6H8N2O3S
- IUPAC Name:
- 2,4-diaminobenzenesulphonic acid
- Test material form:
- solid: particulate/powder
- Remarks:
- migrated information: powder
- Details on test material:
- - Name of test material (as cited in study report): 2,4-Diaminobenzenesulfonic acid- Molecular formula : C6H8N2O3S- Molecular weight : 188.206 g/mol- Smiles notation: O=S(=O)(O)c1c(N)cc(N)cc1- InChl: 1S/C6H8N2O3S/c7-4-1-2-6(5(8)3-4)12(9,10)11/h1-3H,7-8H2,(H,9,10,11)- Substance type: Organic- Physical state: Solid
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- not specified
- Details on test animals or test system and environmental conditions:
- No data available
Test system
- Type of coverage:
- not specified
- Preparation of test site:
- not specified
- Vehicle:
- not specified
- Controls:
- not specified
- Amount / concentration applied:
- 500 mg
- Duration of treatment / exposure:
- 24 h
- Observation period:
- No data available
- Number of animals:
- No data available
- Details on study design:
- no data
Results and discussion
In vivo
Results
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- other: 24 h
- Reversibility:
- no data
- Remarks on result:
- other: moderately irritant to rabbit skin
Applicant's summary and conclusion
- Interpretation of results:
- moderately irritating
- Remarks:
- Migrated informationCriteria used for interpretation of results: EU
- Conclusions:
- The substance 1,3-Phenylenediamine-4-sulfonic acid was considered to be moderately irritant to rabbit skin.
- Executive summary:
Skin irritation test was conducted to evaluate the irritation potential of 1,3-Phenylenediamine-4-sulfonic acid.
500 mg of test substance was administered on to the skin of rabbit. Moderate irritation effects were observed. Therefore, the substance 1,3-Phenylenediamine-4-sulfonic acid was considered to be moderately irritant to rabbit skin.
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