Registration Dossier

Diss Factsheets

Administrative data

Endpoint:
dermal absorption in vivo
Type of information:
migrated information: read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
supporting study
Study period:
1994
Reliability:
2 (reliable with restrictions)

Data source

Reference
Reference Type:
publication
Title:
Study of Lithium Absorption by Users of Spas Treated with Lithium Ion
Author:
McCarty J.D. et al
Year:
1994
Bibliographic source:
Human and Experimental Toxicology May 1994 vol. 13 no. 5 315-319

Materials and methods

Test guideline
Qualifier:
no guideline followed
GLP compliance:
not specified

Test material

Constituent 1
Reference substance name:
Lithium ion
IUPAC Name:
Lithium ion
Radiolabelling:
no

Test animals

Species:
other: human
Strain:
not specified
Sex:
male/female

Administration / exposure

Type of coverage:
other: spa bathing water at 101 ± 2 °F
Vehicle:
water
Duration of exposure:
20 minutes per day, 4 days a week for two consecutive weeks
Doses:
approximately 40 mg lithium ion / L
Control animals:
yes
Details on study design:
Control spa: 0.02 mg lithium ion / L

Results and discussion

Signs and symptoms of toxicity:
no effects
Dermal irritation:
no effects
Absorption in different matrices:
At all stages of the 2 week exposure, there was no statistically significant difference in the serum lithium levels of the test and control groups

Applicant's summary and conclusion

Conclusions:
Exposure to lithium via the skin, does not cause an increase in serum lithium levels.
Executive summary:

The lithium ion is unlikely to penetrate the skin as no significant difference in serum lithium levels was observed between healthy volunteers exposed to 40 mg lithium ion / L in spa water for 20 minutes per day, 4 days per week for two consecutive weeks, when compared to controls exposed to spa water containing to 0.02 mg lithium ion / L for the same time period.