Registration Dossier
Registration Dossier
Diss Factsheets
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EC number: 242-999-8 | CAS number: 19370-86-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Dermal absorption
Administrative data
- Endpoint:
- dermal absorption in vivo
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- supporting study
- Study period:
- 1994
- Reliability:
- 2 (reliable with restrictions)
Data source
Reference
- Reference Type:
- publication
- Title:
- Study of Lithium Absorption by Users of Spas Treated with Lithium Ion
- Author:
- McCarty J.D. et al
- Year:
- 1 994
- Bibliographic source:
- Human and Experimental Toxicology May 1994 vol. 13 no. 5 315-319
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Lithium ion
- IUPAC Name:
- Lithium ion
Constituent 1
- Radiolabelling:
- no
Test animals
- Species:
- other: human
- Strain:
- not specified
- Sex:
- male/female
Administration / exposure
- Type of coverage:
- other: spa bathing water at 101 ± 2 °F
- Vehicle:
- water
- Duration of exposure:
- 20 minutes per day, 4 days a week for two consecutive weeks
- Doses:
- approximately 40 mg lithium ion / L
- Control animals:
- yes
- Details on study design:
- Control spa: 0.02 mg lithium ion / L
Results and discussion
- Signs and symptoms of toxicity:
- no effects
- Dermal irritation:
- no effects
- Absorption in different matrices:
- At all stages of the 2 week exposure, there was no statistically significant difference in the serum lithium levels of the test and control groups
Applicant's summary and conclusion
- Conclusions:
- Exposure to lithium via the skin, does not cause an increase in serum lithium levels.
- Executive summary:
The lithium ion is unlikely to penetrate the skin as no significant difference in serum lithium levels was observed between healthy volunteers exposed to 40 mg lithium ion / L in spa water for 20 minutes per day, 4 days per week for two consecutive weeks, when compared to controls exposed to spa water containing to 0.02 mg lithium ion / L for the same time period.
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