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EC number: 944-170-2 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Ecotoxicological Summary
Administrative data
Hazard for aquatic organisms
Freshwater
- Hazard assessment conclusion:
- PNEC aqua (freshwater)
- PNEC value:
- 0.013 mg/L
- Assessment factor:
- 10
- Extrapolation method:
- assessment factor
- PNEC freshwater (intermittent releases):
- 0.015 mg/L
Marine water
- Hazard assessment conclusion:
- PNEC aqua (marine water)
- PNEC value:
- 0.001 mg/L
- Assessment factor:
- 100
- Extrapolation method:
- assessment factor
- PNEC marine water (intermittent releases):
- 0.002 mg/L
STP
- Hazard assessment conclusion:
- PNEC STP
- PNEC value:
- 4.5 mg/L
- Assessment factor:
- 10
- Extrapolation method:
- assessment factor
Sediment (freshwater)
- Hazard assessment conclusion:
- PNEC sediment (freshwater)
- PNEC value:
- 0.246 mg/kg sediment dw
- Extrapolation method:
- equilibrium partitioning method
Sediment (marine water)
- Hazard assessment conclusion:
- PNEC sediment (marine water)
- PNEC value:
- 0.025 mg/kg sediment dw
- Extrapolation method:
- equilibrium partitioning method
Hazard for air
Air
- Hazard assessment conclusion:
- no hazard identified
Hazard for terrestrial organisms
Soil
- Hazard assessment conclusion:
- PNEC soil
- PNEC value:
- 0.042 mg/kg soil dw
- Extrapolation method:
- equilibrium partitioning method
Hazard for predators
Secondary poisoning
- Hazard assessment conclusion:
- no potential for bioaccumulation
Additional information
Relevant data used for calculation of PNECs
Short-term toxicity to fish |
96 h LC50 >100 mg a.i./L |
Long-term toxicity to fish |
100 d NOEC = 0.135 mg a.i./L |
Short-term toxicity to aquatic invertebrates |
48 h EC50 = 1.9 mg a. i./L |
Long -term toxicity to aquatic invertebrates |
21 d NOEC = 0.3 mg a.i./L |
Toxicity to aquatic algae and cyanobacteria |
72 h ErC50 = 1.5 mg a.i./L 72 h NOEC = 0.3 mg a.i./L |
PNEC aqua (freshwater), PNEC aqua (marine water),
Acute and chronic freshwater aquatic toxicity studies with fish, Daphnia and algae are available for the substance itself or closely related source substances. In accordance with the Guidance on information requirements and chemical safety assessment, Chapter R.10: Characterisation of dose [concentration]-response for environment, 2008, an assessment factor of 10 was applied to the lowest chronic toxicity value (fish early life stage test: 100 d NOEC = 0.135 mg a.i./L). Based on the available data, a PNECaqua (freshwater) = 0.0135 mg/L was calculated.
For derivation of the PNECaqua (marine water) an assessment factor of 100 was applied to the lowest chronic toxicity value (fish early life stage test: 100 d NOEC = 0.135 mg a.i./L). Based on the available data, a PNECaqua (marine water) = 0.00135 mg/L was calculated.
PNEC aqua (intermittent release)
Acute freshwater aquatic toxicity studies with fish, Daphnia and algae are available. An assessment factor of 100 was applied to the lowest value of acute freshwater ecotoxicity test results (72 h ErC50 = 1.5 mg a.i./L in algae) in accordance with the Guidance on information requirements and chemical safety assessment R10. Based on the available data, a PNEC aqua (intermittent releases) = 0.015 mg/L was calculated.
PNEC STP
A test on ready biodegradation including a toxicity control is available. In accordance with the Guidance on information requirements and chemical safety assessment, Chapter R.10: Characterisation of dose [concentration]-response for environment, 2008, an assessment factor of 10 was applied to the 14 d NOEC obtained in the Ready Biodegradability test of 45 mg a.i./L resulting in a PNEC STP of 4.5 mg/L.
PNEC sediment(freshwater), PNEC sediment (marine waters), PNEC(soil)
No toxicity data for soil and sediment dwelling organisms are available. Thus, the PNEC for freshwater and marine sediment as well as for soil has been calculated with the equilibrium partitioning method using EUSES 2.1.
The PNEC sediment(freshwater) was calculated to be 0.246 mg/kg sediment dw; the PNEC sediment (marine waters) was calculated to be 0.0246 mg/kg sediment dw; the PNEC(soil) was calculated to be 0.0421 mg/kg soil dw.
The following data have been taken into account for calculation:
Molecular Weight |
297 mg/mol (weighted mean) |
Melting point |
n.a. (decomposition in the range between 60 and 260°C) |
Vapour Pressure |
0.0031 hPa at 20°C |
Water solubility |
4.9 g/L at 20°C (CMC) |
Log Kow |
2.2 at 20°C |
PNEC freshwater |
0.0135 mg/L |
PNEC marine water |
0.00135 mg/L |
PNEC Air
Due to the ionic structure and a corresponding low vapour pressure of the substance a relevant concentration of the substance in the atmospheric compartment is not expected.
PNEC oral (secondary poisoning)
Bioaccumulation may be of concern for lipophilic organic substances. Secondary poisoning is concerned with toxic effects at the higher level in the food chain, either living in the aquatic or terrestrial compartment.
However, with a log Kow = 2.2 the substance doesn’t meet the screening criteria for bioaccumulation, following the Guidance on information requirements and chemical safety assessment, Chapter R.11 (2012).
Therefore, the biomagnification potential of the substance is expected to be low and secondary poisoning is unlikely. Thus, no PNECoral (secondary poisoning) was derived.
Conclusion on classification
Based on acute toxicity values >1 mg/L, no classification for aquatic acute toxicity is required according to GHS Regulation EC No 1272/2008.
Chronic toxicity values between 0.1 and 1 mg/L were obtained, and the substance is readily biodegradable. Thus, according to GHS Regulation EC No 1272/2008, C8-10 Alkylamidopropyl betaine is classified as Aquatic Chronic 3.
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