Registration Dossier
Registration Dossier
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EC number: 216-305-9 | CAS number: 1555-58-4
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- publication
- Title:
- Range-Finding Toxicity data List V
- Author:
- Smyth Jr H.F., Carpenter C.P., Weil C.S., Pozzani U.C.
- Year:
- 1 954
- Bibliographic source:
- AMA Arch. Ind. Hyg. Occup. Med. 10, 61-68 (1954)
Materials and methods
- Principles of method if other than guideline:
- Single dose oral toxicity for rats was estimated by intubation of dosages in a logarithmic series to groups of five male rats. Dosing was followed by a 14 day observation period.
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- 3,3'-(methylimino)bispropiononitrile
- EC Number:
- 216-305-9
- EC Name:
- 3,3'-(methylimino)bispropiononitrile
- Cas Number:
- 1555-58-4
- Molecular formula:
- C7H11N3
- IUPAC Name:
- 3-[(2-cyanoethyl)(methyl)amino]propanenitrile
- Test material form:
- liquid
Constituent 1
- Specific details on test material used for the study:
- - Name as used in publication: N-Methyl-3,3'-iminodipropionitrile
Test animals
- Species:
- rat
- Strain:
- other: Carworth-Wistar
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS- Source: Raised on the premises (Mellon Institute of Industrial Research, University of Pittsburgh)- Weight at study initiation: 90-120 g- Fasting period before study: no- Diet: Rockland diet complete
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- other:
- Remarks:
- water, corn oil, or 1% solution of sodium 3,9-diethyl-6-tridecanol
- Details on oral exposure:
- VEHICLE - Amount of vehicle: between 1 and 10 mL
- Doses:
- Logarithmic series
- No. of animals per sex per dose:
- 5
- Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: 14 days
- Statistics:
- Probable LD50 value and its fiducial range were estimated by the method of Thompson using the tables of Weil.
Results and discussion
Effect levels
- Key result
- Dose descriptor:
- LD50
- Effect level:
- 890 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- >= 610 - <= 1 310
Applicant's summary and conclusion
- Interpretation of results:
- Category 4 based on GHS criteria
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