Registration Dossier
Registration Dossier
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EC number: 216-305-9 | CAS number: 1555-58-4
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- publication
- Title:
- Range-Finding Toxicity data List V
- Author:
- Smyth Jr H.F., Carpenter C.P., Weil C.S., Pozzani U.C.
- Year:
- 1 954
- Bibliographic source:
- AMA Arch. Ind. Hyg. Occup. Med. 10, 61-68 (1954)
Materials and methods
- Principles of method if other than guideline:
- Study performed similar to the one-day cuff method of Draize (Draize, J.H. et al.: J. Pharmacol. Exp. Therap. 82, 377)
- GLP compliance:
- no
- Test type:
- fixed dose procedure
- Limit test:
- no
Test material
- Reference substance name:
- 3,3'-(methylimino)bispropiononitrile
- EC Number:
- 216-305-9
- EC Name:
- 3,3'-(methylimino)bispropiononitrile
- Cas Number:
- 1555-58-4
- Molecular formula:
- C7H11N3
- IUPAC Name:
- 3-[(2-cyanoethyl)(methyl)amino]propanenitrile
- Test material form:
- liquid
Constituent 1
- Specific details on test material used for the study:
- - Name as used in publication: N-Methyl-3,3'-iminodipropionitrile
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Remarks:
- giant albino
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS- Weight at study initiation: 2.5 to 3.5 kg
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- not specified
- Details on dermal exposure:
- The fur of the animals was closely clipped over the entire trunk, and the dose, retained beneath an impervious plastic film, contacts about 1/10 of the body surface. After 24 hours contact the film was removed
- Duration of exposure:
- 24 hours
- No. of animals per sex per dose:
- 4
- Control animals:
- not specified
- Details on study design:
- Duration of observation period following administration: 14 days
Results and discussion
Effect levels
- Key result
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- ca. 0.8 mL/kg bw
- Based on:
- test mat.
- 95% CL:
- >= 0.93 - <= 1.62
Applicant's summary and conclusion
- Interpretation of results:
- Category 3 based on GHS criteria
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