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Administrative data

Endpoint:
vapour pressure
Type of information:
experimental study
Adequacy of study:
key study
Study period:
13 March 2012- 11 July 2012
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: The study has been performed according to OECD and EC guidelines and according to the principles of GLP.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2012
Report date:
2012

Materials and methods

Test guidelineopen allclose all
Qualifier:
according to guideline
Guideline:
EU Method A.4 (Vapour Pressure)
Version / remarks:
(2009)
Deviations:
no
Qualifier:
according to guideline
Guideline:
OECD Guideline 104 (Vapour Pressure Curve)
Version / remarks:
(2006)
Deviations:
no
Qualifier:
according to guideline
Guideline:
EPA OPPTS 830.7950 (Vapor Pressure)
Version / remarks:
(1996)
Deviations:
no
GLP compliance:
yes
Type of method:
effusion method: by loss of weight or by trapping vaporisate
Remarks:
(Isothermal thermogravimetric effusion method)

Test material

Constituent 1
Chemical structure
Reference substance name:
2,5-anhydro-4-{[4-(4-{4-[({1-[(2S,3S)- 2-(benzyloxy)pentan-3-yl]hydrazino}carbonyl)amino]phenyl}piperazin1-yl)phenoxy]methyl}-1,3,4-trideoxy-2-(2,4-difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)-
EC Number:
701-059-1
Cas Number:
345217-03-0
Molecular formula:
C43H50F2N8O4
IUPAC Name:
2,5-anhydro-4-{[4-(4-{4-[({1-[(2S,3S)- 2-(benzyloxy)pentan-3-yl]hydrazino}carbonyl)amino]phenyl}piperazin1-yl)phenoxy]methyl}-1,3,4-trideoxy-2-(2,4-difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)-
Test material form:
solid: particulate/powder
Remarks:
migrated information: powder
Details on test material:
- Name of test material (as cited in study report): PAZ-D
- Physical state: white powder
- Hygroscopic

Results and discussion

Vapour pressureopen allclose all
Temp.:
20 °C
Vapour pressure:
< 8.4 other: E-7 Pa
Remarks on result:
other: <6.3 E-9 mm Hg
Temp.:
25 °C
Vapour pressure:
< 2.9 other: E-6 Pa
Remarks on result:
other: < 2.2 E-8 mm Hg

Any other information on results incl. tables

The weight loss of the test substance at 170°C, 180°C, 190°C and 200°C was lower than the weight loss of chrysene at the same temperatures.

Applicant's summary and conclusion

Conclusions:
Using the isothermal thermogravimetric effusion method, the vapour pressure of the substance was determined to be < 2.9 E-6 Pa at 25°C (< 8.4 E-7 Pa at 20°C). The study was performed in accordance with EC A.4, OECD 104 and EPA OPPTS 830.7950 guidelines and according to the principles of GLP.