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EC number: 212-889-4 | CAS number: 877-24-7
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- Data is from authoritative database
Data source
Referenceopen allclose all
- Reference Type:
- review article or handbook
- Title:
- Acute oral toxicity of CAS no 877-24-7
- Author:
- U.S. Government
- Year:
- 2 017
- Bibliographic source:
- RTECS database, U.S. Government, 2017
- Reference Type:
- review article or handbook
- Title:
- Acute oral toxicity of CAS no 877-24-7
- Author:
- John Wiley & Sons
- Year:
- 2 012
- Bibliographic source:
- SAX: Chemical Card, 2012
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: as below
- Principles of method if other than guideline:
- Acute oral toxicity study of 1,2-Benzenedicarboxylic acid, monopotassium salt in rats
- GLP compliance:
- not specified
- Test type:
- other: not specified
- Limit test:
- no
Test material
- Reference substance name:
- Potassium hydrogen phthalate
- EC Number:
- 212-889-4
- EC Name:
- Potassium hydrogen phthalate
- Cas Number:
- 877-24-7
- Molecular formula:
- C8H6O4.K
- IUPAC Name:
- phthalic acid
Constituent 1
- Specific details on test material used for the study:
- Name: 1,2-Benzenedicarboxylic acid, monopotassium salt
Molecular Formulas: C8H5O4.K
C8H6O4.K
Molecular Weight: 204.221 g/mole
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- No data available
Administration / exposure
- Route of administration:
- oral: unspecified
- Vehicle:
- not specified
- Details on oral exposure:
- No data available
- Doses:
- 3200 mg/kg bw
- No. of animals per sex per dose:
- No data available
- Control animals:
- not specified
- Details on study design:
- No data available
- Statistics:
- No data available
Results and discussion
- Preliminary study:
- No data available
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- > 3 200 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: No mortality observed
- Mortality:
- No mortality was observed in treated rats at 3200 mg/kg bw
- Clinical signs:
- other: No data available
- Gross pathology:
- No data available
- Other findings:
- No data available
Applicant's summary and conclusion
- Interpretation of results:
- other: Not Classified
- Conclusions:
- LD50 was considered to >3200 mg/kg bw when rats were treated with 1,2-Benzenedicarboxylic acid, monopotassium salt orally.
- Executive summary:
In a acute oral toxicity study, rats were treated with1,2-Benzenedicarboxylic acid, monopotassium salt in the concentration of 3200 mg/kg bw. No mortality was observed in treated rats at 3200 mg/kg bw.Therefore,LD50 was considered to >3200 mg/kg bw when rats were treated with1,2-Benzenedicarboxylic acid, monopotassium salt orally.
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