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Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Justification for type of information:
Data is from authoritative database

Data source

Referenceopen allclose all

Reference Type:
review article or handbook
Title:
Acute oral toxicity of CAS no 877-24-7
Author:
U.S. Government
Year:
2017
Bibliographic source:
RTECS database, U.S. Government, 2017
Reference Type:
review article or handbook
Title:
Acute oral toxicity of CAS no 877-24-7
Author:
John Wiley & Sons
Year:
2012
Bibliographic source:
SAX: Chemical Card, 2012

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: as below
Principles of method if other than guideline:
Acute oral toxicity study of 1,2-Benzenedicarboxylic acid, monopotassium salt in rats
GLP compliance:
not specified
Test type:
other: not specified
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Potassium hydrogen phthalate
EC Number:
212-889-4
EC Name:
Potassium hydrogen phthalate
Cas Number:
877-24-7
Molecular formula:
C8H6O4.K
IUPAC Name:
hydrogen potassium phthalate
Specific details on test material used for the study:
Name: 1,2-Benzenedicarboxylic acid, monopotassium salt
Molecular Formulas: C8H5O4.K
C8H6O4.K
Molecular Weight: 204.221 g/mole

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified
Details on test animals or test system and environmental conditions:
No data available

Administration / exposure

Route of administration:
oral: unspecified
Vehicle:
not specified
Details on oral exposure:
No data available
Doses:
3200 mg/kg bw
No. of animals per sex per dose:
No data available
Control animals:
not specified
Details on study design:
No data available
Statistics:
No data available

Results and discussion

Preliminary study:
No data available
Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
> 3 200 mg/kg bw
Based on:
test mat.
Remarks on result:
other: No mortality observed
Mortality:
No mortality was observed in treated rats at 3200 mg/kg bw
Clinical signs:
No data available
Body weight:
No data available
Gross pathology:
No data available
Other findings:
No data available

Applicant's summary and conclusion

Interpretation of results:
other: Not Classified
Conclusions:
LD50 was considered to >3200 mg/kg bw when rats were treated with 1,2-Benzenedicarboxylic acid, monopotassium salt orally.
Executive summary:

In a acute oral toxicity study, rats were treated with1,2-Benzenedicarboxylic acid, monopotassium salt in the concentration of 3200 mg/kg bw. No mortality was observed in treated rats at 3200 mg/kg bw.Therefore,LD50 was considered to >3200 mg/kg bw when rats were treated with1,2-Benzenedicarboxylic acid, monopotassium salt orally.

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