Androsta-1,4-diene-17-carbothioic acid, 6,9-difluoro-11-hydroxy-16-methyl-3-oxo-17-(1-oxopropoxy)-, (6.alpha.,11.beta.,16.alpha.,17.alpha.)-

Vapour pressure

Link to relevant study record(s)

Reference

Endpoint:

vapour pressure

Type of information:

experimental study

Adequacy of study:

key study

Study period:

24th April 2015 - 29th April 2015

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

EU Method A.4 (Vapour Pressure)

Deviations:

no

GLP compliance:

yes

Type of method:

static method

Key result

Temp.:

ca. 20 °C

Vapour pressure:

ca. 6 Pa

Remarks on result:

other: Mean of runs 1 & 2

Full Test results:

Temp / °C	Temp / K	P / mbar	**P / Pa
Run 1
*20	293.15	0.06	6
19.4	292.55	0.0511	5.11
29.7	302.85	0.3752	37.52
40.6	313.75	2.3	230
49.4	322.55	11.6	1160
Run 2
*20	293.15	0.06	6
20.1	293.25	0.0576	5.76
28.2	301.35	0.35	35
39.2	312.35	2.1	210
47.9	321.05	11.9	1190

* - Determined by interpolation

** - Calculated

Comments:

Sample is suspected to be solvent wet. Although moisture content analysis revealed < 0.2%, the nature of the solvent is unknown. Solvent properties must therefore be considered when interpreting the result as volatile impurities may significantly affect the vapour pressure result. Approximately 10 g of material was used.

Conclusions:

Result : 6.0 Pa at 20°C (mean of runs 1 & 2)

Executive summary:

The test is conducted to determine the vapour pressure of a test substance by the Static method – using a U-tube manometer.

The static method involves placing a sample in a bulb maintained at constant temperature and connected to a pressure monitor and a vacuum pump. The method is suitable for multi-component systems. Results are subject to only slight errors for sample containing non-volatile impurities. The recommended range is 10 to 10⁵ Pa.

The test is conducted in accordance with the procedure described in EU Regulation (EC) 440/2008, Annex Part A test A4.

Result : 6.0 Pa at 20°C (mean of runs 1 & 2)

Description of key information

The test is conducted to determine the vapour pressure of a test substance by the Static method – using a U-tube manometer.

The static method involves placing a sample in a bulb maintained at constant temperature and connected to a pressure monitor and a vacuum pump. The method is suitable for multi-component systems. Results are subject to only slight errors for sample containing non-volatile impurities. The recommended range is 10 to 10⁵Pa.

The test is conducted in accordance with the procedure described in EU Regulation (EC) 440/2008, Annex Part A test A4.

Result : 6.0 Pa at 20°C (mean of runs 1 & 2)

Key value for chemical safety assessment

Vapour pressure:

6 Pa

at the temperature of:

20 °C