Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

First-aid measures

Ingestion:                     Never attempt to induce vomiting. Do not attempt to give any solid or liquid by mouth if the exposed subject is unconscious or semi-conscious.                            Wash out the mouth with water. If the exposed subject is fully conscious, give plenty of water to drink. Obtain medical attention.

Inhalation:                     Using appropriate personal protective equipment, move exposed subject to fresh air. If breathing is difficult or ceases, ensure and maintain                            ventilation. Give oxygen as appropriate. The exposed subject should be kept warm and at rest. Obtain medical attention in cases of known or                            possible over exposure, or with symptoms including chest pain, difficulty breathing, loss of consciousness or other adverse effects, which                            may be delayed.

Skin contact:                Using appropriate personal protective equipment, remove contaminated clothing and flush exposed area with large amounts of water. Obtain                            medical attention if skin reaction occurs, which may be immediate or delayed.

Eye contact:                     Wash immediately with clean and gently flowing water. Continue for at least 15 minutes. Obtain medical attention.


Medical Treatment:              In allergic individuals, exposure to this material may require treatment for initial or delayed allergic symptoms and signs. This may include                            immediate and/or delayed treatment of anaphylactic reactions.

                    Treat according to locally accepted protocols. For additional guidance, refer to the local poison control information centre.

Medical Conditions

Caused or Aggravated by

Exposure:                     Ocular symptoms may be indicative of allergic reaction.

Health Surveillance

Procedures:                     The need for pre-placement and periodic health surveillance must be determined by risk assessment. Following assessment, if the risk of                            exposure is considered significant then exposed individuals should receive health surveillance focused on detecting skin conditions.

                    In the event of overexposure, individuals should receive post exposure health surveillance focused on detecting skin conditions and other                            allergy symptoms.

Antidotes:                     No specific antidotes are recommended.

Fire-fighting measures

Fire and Explosion Hazards:       This material is combustible.

                    Dust clouds are potentially sensitive to ignition from incendive electrostatic discharges.

                    Dust clouds are of low sensitivity to ignition from hot surfaces.

                    No ignition or exotherm of a powder layer observed up to 400 °C.

                    Ignition of a dust cloud produces a strong dust explosion.

                    High pressure between 8 and 10 bar is produced during a dust explosion.

Suitable Extinguishing Media:       Water, dry powder or foam extinguishers are recommended. Carbon dioxide extinguishers may be ineffective.

Special Protective Equipment and Precautions for Firefighters:

                    Since toxic, corrosive or flammable vapours might be evolved from fires involving this material, self contained breathing apparatus and full                            protective equipment are recommended for firefighters.

                    Move containers from the fire area if possible without increased personal risk.

                    If possible, contain and collect firefighting water for later disposal.

Specific Hazards arising from the Material:

                    Toxic, corrosive or flammable thermal decomposition products, which might include fluorine and sulphur compounds, are expected when the                            material is exposed to fire.

Accidental release measures

Personal Precautions:              Fence or cordon the affected area and do not allow individuals to touch or walk through the spilled material unless wearing appropriate protective                     clothing. Avoid dust generation.

Environmental Precautions:       Prevent entry into waterways, sewers, surface drainage systems and poorly ventilated areas. If spill is outdoors, cover with plastic sheet to                            minimise spreading or contact with rain.

Clean-up Methods:              Collect and place it in a suitable, properly labelled container for recovery or disposal. After all solid or absorbent material has been collected,                            the area should be vacuumed with HEPA filter-equipped apparatus.

Decontamination Procedures:       No specific decontamination or detoxification procedures have been identified for this material.

                    Consider use of water, detergent solutions, or other soluble solvents (if specified in Section 9 of this SDS), for clean-up and decontamination                            operations.

Handling and storage


General Requirements:              Avoid dispersion as a dust cloud.

                    Depending upon the scale of operation, use of appropriate exhaust ventilation is recommended to provide routine control of fire and explosion                            hazards during handling of this material.

Ignition Controls:              Any mechanical operations used for particle size reduction should be performed in a manner that do not produce localised heating.

                    Bond and earth (ground) all plant and equipment to ensure that no isolated conductors are present. Isolated conductors can accumulate                            sufficient electrostatic charge to produce discharges of many hundreds of milli-Joules.

                    Consider earthing (grounding) personnel dealing with dusty operations. An isolated (insulated) human body can readily produce electrostatic                            discharges in excess of 50 mJ, but have been recorded up to 100 mJ.

                    The maximum surface temperature of enclosures potentially exposed to this material should be the lower of the values obtained by taking 2/3                            of the minimum ignition temperature for a dust cloud or 75 K less than the minimum ignition temperature of the dust layer, with a maximum

                    temperature of 325 °C.

Protective Systems:              Assess operations based upon available dust explosion information to determine the suitability of preventive or protective systems as                            precautionary measures against possible dust explosions. If prevention is not possible, consider protection by use of containment, venting or                            suppression of dust handling equipment. Where explosion venting is considered the most appropriate method of protection, vent areas should                            preferably be calculated based on the Kst rather than the St value.

                    If nitrogen purging is considered as the protective system, it must operate with an oxygen level below the limiting oxygen concentration. The                            system should include an oxygen monitoring and shut-down facility in the event of excessive oxygen being detected.

                    At both ambient and low humidity, this material is of low conductivity. Generation of electrostatic charge is considered likely to occur even                            when handled in an earthed (grounded) environment.

                    At both ambient and low humidity, this material has an extremely long charge relaxation time.

                    Accumulation of electrostatic charge will occur even when handled in an earthed (grounded) environment. Under these conditions, it is                            considered that this material might present a very high risk of producing an electrostatic discharge.


STORAGE:                     Keep in tightly closed containers or packages away from moisture and away from sources of ignition.

                    Avoid prolonged storage at elevated temperatures (greater than room temperature, approximately 20 degrees C).

Transport information

Land transport (UN RTDG/ADR/RID)

UN number:
Not regulated in transport
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Marine transport (UN RTDG/IMDG)

UN number:
Not regulated in transport
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Air transport (UN RTDG/ICAO/IATA)

UN number:
Not regulated in transport
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Exposure controls / personal protection


Exposure Controls:              This material has been assigned to GlaxoSmithKline Occupational Hazard Category 3 with a hygiene guide of 10-<100 mcg/m3. An Exposure                            Control Approach (ECA) is established for operations involving this material based upon the OEL/Occupational Hazard Category and the

                    outcome of a site- or operation-specific risk assessment. Refer to the Exposure Control Matrix for more information about how ECA's are                            assigned and how to interpret them.

Containment:              Open handling is not recommended. Consider segregating operations, use of enclosures and sealed transfer systems.

Ventilation:                     Local exhaust ventilation (LEV) should be used in conjunction with other control measures as a means of removing material incidentally                            released.

Administrative:              Entry to the working area should be controlled.


Eye Protection:               Wear approved safety glasses with side shields or cover goggles if eye contact is possible.

Gloves:                     The selection of gloves for a specific activity must be based on the material's properties and on possible permeation and degradation that may                            occur under the circumstances of use. Glove selection must take into account any solvents and other hazards present. Potential allergic

                    reactions can occur with certain glove materials (e.g. Latex) and therefore these should be avoided. Care must be exercised if insufficient                            data are available and further guidance should be sought from your local EHS department.

Respirators:                     If respiratory protective equipment (RPE) is used, the type of RPE will depend upon air concentrations present, required protection factor as                            well as hazards, physical properties and warning properties of substances present. Follow local regulations for respirator use in the                            workplace.

Other Equipment or

Procedures:                     An eye wash station should be available. Consider control procedures for maintenance, cleaning and emergencies.

Stability and reactivity

Conditions to Avoid:              Avoid direct sunlight, conditions that might generate heat and dispersion as a dust cloud.

Disposal considerations

Disposal Recommendations:       Collect for recycling or recovery if possible. The recommended method of disposal is incineration.

                    Wherever possible, disposal should be in an on-site licenced chemical incinerator, if allowed by the incinerator licence or permit. If no on-site                                   incinerator is available, dispose of material in a licenced commercial chemical incinerator.

Regulatory Requirements:              Observe all local and national regulations when disposing of this material.