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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: dermal

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Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
key study
Study period:
1977
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Basic data given:comparable to guidelines/standards.
Cross-referenceopen allclose all
Reason / purpose for cross-reference:
read-across: supporting information
Reference
Endpoint:
acute toxicity: dermal
Type of information:
read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
key study
Study period:
1977
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Basic data given:comparable to guidelines/standards.
Reason / purpose for cross-reference:
read-across source
Reason / purpose for cross-reference:
reference to same study
Key result
Sex:
male/female
Dose descriptor:
LD50
Effect level:
> 4 mL/kg bw
Mortality:
No animals died during the study.

Mortality

Dose ml/kg

Males

Female

Total

1

0/2

0/2

0/4

2

0/2

0/2

0/4

4

0/2

0/2

0/4

Interpretation of results:
study cannot be used for classification
Conclusions:
The dermal LD50 for rats is > 4 ml/kg (~3400 mg/ kg bw).
Executive summary:

This data is being read across from the source study that tested Hydrocarbons, C9-C12, n-alkanes, isoalkanes, cyclics, aromatics (2-25%) based on analogue read across.

This study examined the acute toxicity of Dilutine M5 to rats via dermal exposure. 2 female and 2 male rats were exposed to 1, 2, or 4 ml/kg of undiluted test material dermally for 24 hrs. No rats died during the experiment. The dermal LD50 for rats is > 4 ml/kg (~3400mg/kg bw).

Reason / purpose for cross-reference:
reference to same study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1977

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: Noakes, DN, and Sanderson, DM (1969). A method for determining the dermal toxicity of pesticides. Br. J. Industr. Med., 26, 59-64.
GLP compliance:
no
Limit test:
yes

Test material

Test animals

Species:
rat
Strain:
Crj: CD(SD)
Sex:
male/female
Details on test animals or test system and environmental conditions:
TEST ANIMALS
- Source: Charles River (UK) Ltd, Manston, Kent

Administration / exposure

Vehicle:
unchanged (no vehicle)
Details on dermal exposure:
TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 1, 2, or 4 ml/kg
Duration of exposure:
24 hrs
Doses:
1, 2, 4 ml/kg
No. of animals per sex per dose:
2 animals of each sex per dose

Results and discussion

Effect levels
Key result
Sex:
male/female
Dose descriptor:
LD50
Effect level:
> 4 mL/kg bw
Mortality:
No animals died during the study.

Any other information on results incl. tables

Mortality

Dose ml/kg

Males

Female

Total

1

0/2

0/2

0/4

2

0/2

0/2

0/4

4

0/2

0/2

0/4

Applicant's summary and conclusion

Interpretation of results:
study cannot be used for classification
Conclusions:
The dermal LD50 for rats is > 4 ml/kg (~3400 mg/ kg bw).
Executive summary:

This study examined the acute toxicity of Dilutine M5 to rats via dermal exposure. 2 female and 2 male rats were exposed to 1, 2, or 4 ml/kg of undiluted test material dermally for 24 hrs. No rats died during the experiment. The dermal LD50 for rats is > 4 ml/kg (~3400mg/kg bw).