Registration Dossier
Registration Dossier
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EC number: 218-941-2 | CAS number: 2295-31-0
Toxicity to microorganisms
Administrative data
Link to relevant study record(s)
- Endpoint:
- toxicity to microorganisms, other
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Qualifier:
- according to guideline
- Guideline:
- other: Refer below principle
- Principles of method if other than guideline:
- Antibacterial activity observed of test substance 1,3-thiazolidine-2,4-dione in bacterial species Pseudomonas aeruginosa UFPEDA 39 strain,Escherichia coli UFPEDA 224 strain,Serratia marcescens UFPEDA 398 strain,Staphylococcus aureus UFPEDA 01 strain,Mycobacterium smegmatis UFPEDA 71 strain,Enterococcus faecalis UFPEDA 138 strain,Micrococcus luteus UFPEDA 06 strain,Bacillus subtilis UFPEDA 16 strain and fungal species Candida albicans UFPEDA 1007 strain at dose concentration 300 μg/disc.
- GLP compliance:
- not specified
- Specific details on test material used for the study:
- - Name of test material (as cited in study report): 2,4-Thiazolidinedione
- Molecular formula: C3H3NO2S
- Molecular weight: 117.1277 g/mol
- Substance type: organic
- Physical state: Solid
- Smiles notation: C1C(=O)NC(=O)S1
- InChl: 1S/C3H3NO2S/c5-2-1-7-3(6)4-2/h1H2,(H,4,5,6) - Analytical monitoring:
- not specified
- Vehicle:
- yes
- Details on test solutions:
- PREPARATION AND APPLICATION OF TEST SOLUTION (especially for difficult test substances)
- Chemical name of vehicle (organic solvent, emulsifier or dispersant):DMSO - Test organisms (species):
- other: Pseudomonas aeruginosa,Escherichia coli,Serratia marcescens,Staphylococcus aureus,Mycobacterium smegmatis,Enterococcus faecalis,Micrococcus luteus,Bacillus subtilis and Candida albicans
- Details on inoculum:
- Pseudomonas aeruginosa UFPEDA 39 strain,Escherichia coli UFPEDA 224 strain,Serratia marcescens UFPEDA 398 strain,Staphylococcus aureus UFPEDA 01 strain,Mycobacterium smegmatis UFPEDA 71 strain,Enterococcus faecalis UFPEDA 138 strain,Micrococcus luteus UFPEDA 06 strain,Bacillus subtilis UFPEDA 16 strain and fungal species Candida albicans UFPEDA 1007 strain
- Test type:
- not specified
- Water media type:
- freshwater
- Reference substance (positive control):
- not specified
- Key result
- Dose descriptor:
- other: MIC
- Effect conc.:
- 300 other: μg/disc
- Nominal / measured:
- not specified
- Conc. based on:
- test mat.
- Basis for effect:
- other: zone of inhibition
- Remarks on result:
- other: Value of zone of inhibition is < 7 mm
- Validity criteria fulfilled:
- not specified
- Conclusions:
- From Reaxy database the antibacterial activity (MIC) of test chemical 1,3-thiazolidine-2,4-dione i.e 2,4-Thiazolidinedione (Cas no.2295-31-0) was observed at dose concentration 300 μg/disc and value of zone of inhibition is < 7 mm.
- Executive summary:
Antibacterial activity observed of test substance 1,3-thiazolidine-2,4-dione (Cas no.2295 -31 -0) in bacterial species Pseudomonas aeruginosa UFPEDA 39 strain,Escherichia coli UFPEDA 224 strain,Serratia marcescens UFPEDA 398 strain,Staphylococcus aureus UFPEDA 01 strain,Mycobacterium smegmatis UFPEDA 71 strain,Enterococcus faecalis UFPEDA 138 strain,Micrococcus luteus UFPEDA 06 strain,Bacillus subtilis UFPEDA 16 strain and fungal species Candida albicans UFPEDA 1007 strain at dose concentration 300 μg/disc.
Based on the experimental observation of antibacterial activity (MIC) the value of zone of inhibition is < 7 mm.
Reference
Description of key information
From Reaxy database the antibacterial activity (MIC) of test chemical 1,3-thiazolidine-2,4-dione i.e 2,4-Thiazolidinedione (Cas no.2295-31-0) was observed at dose concentration 300 μg/disc and value of zone of inhibition is < 7 mm.
Key value for chemical safety assessment
Additional information
Antibacterial activity observed of test substance 1,3-thiazolidine-2,4-dione (Cas no.2295 -31 -0) in bacterial species Pseudomonas aeruginosa UFPEDA 39 strain,Escherichia coli UFPEDA 224 strain,Serratia marcescens UFPEDA 398 strain,Staphylococcus aureus UFPEDA 01 strain,Mycobacterium smegmatis UFPEDA 71 strain,Enterococcus faecalis UFPEDA 138 strain,Micrococcus luteus UFPEDA 06 strain,Bacillus subtilis UFPEDA 16 strain and fungal species Candida albicans UFPEDA 1007 strain at dose concentration 300 μg/disc.
Based on the experimental observation of antibacterial activity (MIC) the value of zone of inhibition is < 7 mm.
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