Registration Dossier
Registration Dossier
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EC number: 200-562-9 | CAS number: 63-68-3
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 162 mg/L
Additional information
No experimental data is available for L-methionine.
As no toxicity studies for aquatic invertebrates of L-methionine were available, a study performed with D,L-methionine in accordance to GLP and guideline OECD 202 was used as key study (2001-0080-DGO). This study determined the EC50 value after 48 h as 324 mg/l D,L-methionine for Daphnia magna.
Read-across of the D,L-methionine study to L-methionine was used due to structural similarities and the physico-chemical similiarities according to Reach regulation (Annex XI, 1.5). Further, L-methionine is present in a considerable amount in racemic methionine (approximatly 50%). Taking this into account it can be concluded that the EC50 of L-methionine is 162 mg/l as a worst case approach.
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