Tripiperazine dicitrate

pH

Administrative data

Endpoint:

pH

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Justification for type of information:

Experimental test result performed using standard OECD test guidelines

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

2015

Report date:

2015

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

other: OECD 122(pH measurement interface Microlab FS-524 and pH probe)

Principles of method if other than guideline:

The pH of an aqueous solution or dispersion in water is determined with a pH measurement interface equipped with an appropriate electrode system.

GLP compliance:

no

Test material

Test material information

Constituent 1

Reference substance name:

Tripiperazine dicitrate

EC Number:

205-622-8

EC Name:

Tripiperazine dicitrate

Cas Number:

144-29-6

Molecular formula:

C6H8O7.3/2C4H10N2

IUPAC Name:

piperazine 2-hydroxypropane-1,2,3-tricarboxylate (3:2) (salt)

Test material form:

solid: particulate/powder

Remarks:

migrated information: powder

Details on test material:

- Name of test material (as cited in study report): Piperazine Citrate - Molecular formula: C12H30N6•Cl2H16O14 - Molecular weight: 642.76 g/mole - Smiles notation: C1CNCCN1.C1CNCCN1.C1CNCCN1.C(C(=O)O)C(CC(=O)O)(C(=O)O)O.C(C(=O)O)C(CC(=O)O)(C(=O)O)O - Substance type: Organic - Physical state: Solid-Purity:99.0% (BP)

Specific details on test material used for the study:

- Name of test material (as cited in study report): Piperazine citrate / tripiperazine dicitrate- Molecular formula: C12H30N6•Cl2H16O14 - Molecular weight: 642.76 g/mole - Substance type: Organic - Physical state: Solid

Results and discussion

pH value

Key result

pH value:

5.6

Temp.:

26.5 °C

Concentration:

1 other: % w/v

Remarks on result:

other: Acidic in nature

Any other information on results incl. tables

Temperature of 1% w/v test solution	-	26.5°C
pH (RESULT)	-	5.60
Inference	1.   Acidic 2.   Basic 3.   Neutral	Acidic

Applicant's summary and conclusion

Conclusions:

The pH determination of test item Tripiperazine dicitrate (CAS No. 144-29-6) was done following OECD guideline 122. pH of 1% w/v aqueous solution was measured with the help of pH meter/probe and it was observed to be 5.60 at 26.5 °C.

Executive summary:

The pH determination of test item Tripiperazine dicitrate(CAS No. 144-29-6) was done as per the test guideline OECD 122. The pH of the test solution was determined with the help of pH probe. The measurement interface was Micro Lab FS-524; software version 6.2 8b. The pH was found to be 5.60 at 26.5°C.