Registration Dossier
Registration Dossier
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EC number: 619-905-2 | CAS number: 915416-45-4
Partition coefficient
Administrative data
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP guidelind study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 015
- Report date:
- 2015
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- HPLC method
- Partition coefficient type:
- octanol-water
Test material
- Test material form:
- solid: particulate/powder
- Remarks:
- migrated information: powder
- Details on test material:
- Name of test material (as cited in study report): (1 , 1'-Biphenyl) -2-amine,3',4', 5'-trifluoro-
Physical state: solid
Analytical purity: 100.0 % (1H-NMR, see characterization study no. 15L00258)
BASF SE, D-67056 Ludwigshafen
Lot/batch No.: SK03/186
Expiration date of the lot/batch:Mar 22, 2015
Storage condition of test material:Room temperature, protection against humidity
Constituent 1
Study design
- Analytical method:
- high-performance liquid chromatography
Results and discussion
Partition coefficient
- Type:
- log Pow
- Partition coefficient:
- 3.3
- Temp.:
- 23 °C
- pH:
- 6.4
Any other information on results incl. tables
Individual Results
Component |
tr[min] (mean value out of two determinations) |
ks |
log ks |
log Pow |
Formamide |
1.5 |
|
|
|
Benzonitrile |
4.8 |
2.28 |
0.358 |
1.6 |
Acetophenone |
4.5 |
2.04 |
0.311 |
1.7 |
Nitrobenzene |
6.1 |
3.19 |
0.504 |
1.9 |
Anisole |
7.5 |
4.14 |
0.617 |
2.1 |
Ethylbenzoate |
10.2 |
5.93 |
0.773 |
2.6 |
Toluene |
13.0 |
7.89 |
0.897 |
2.7 |
Allylphenylether |
13.4 |
8.16 |
0.912 |
2.9 |
Ethylbenzene |
20.1 |
12.73 |
1.105 |
3.2 |
Phenylbenzoate |
19.5 |
12.31 |
1.090 |
3.6 |
Cumene |
29.7 |
19.23 |
1.284 |
3.7 |
Benzylbenzoate |
24.3 |
15.58 |
1.192 |
4.0 |
Test item |
18.3 |
11.47 |
1.060 |
3.3 |
Result
log Pow = 3.3 at T = 23 °C and pH = 6.4 (pH value of the water used for the preparation of the eluent)
Solubility in n-octanol
Additionally the solubility of the test item in n-octanol was visually tested.
The n-octanol solubility of test item was estimated to be > 11 .09 g/100 g < 49.71 g/100 g at T = 23 °C.
Applicant's summary and conclusion
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