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Toxicological information

Skin irritation / corrosion

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Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Justification for type of information:
data is from authoritative database

Data source

Reference
Reference Type:
other: Authoritative database
Title:
HSDB for the CAS: 108-99-6
Author:
U.S National Library of Medicine
Year:
2015
Bibliographic source:
Hazardous Substances Data Bank (HSDB), U.S National Library of Medicine, last updated 2015

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: as mentioned below
Principles of method if other than guideline:
To assess the dermal irritation potential of 3-methylpyridine in rabbits
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
3-methylpyridine
EC Number:
203-636-9
EC Name:
3-methylpyridine
Cas Number:
108-99-6
Molecular formula:
C6H7N
IUPAC Name:
3-methylpyridine
Test material form:
liquid
Details on test material:
- Name of test material (as cited in study report): 3-methylpyridine
- Molecular formula: C6H7N
- Molecular weight: 93.1283 g/mol
- Substance type: organic
- Physical state: liquid
- Smiles: c1(cccnc1)C
- InChI: 1S/C6H7N/c1-6-3-2-4-7-5-6/h2-5H,1H3
Specific details on test material used for the study:
- Name of test material (as cited in study report): 3-methylpyridine
- Molecular formula: C6H7N
- Molecular weight: 93.1283 g/mol
- Substance type: organic
- Physical state: liquid
- Smiles: c1(cccnc1)C
- InChI: 1S/C6H7N/c1-6-3-2-4-7-5-6/h2-5H,1H3

Test animals

Species:
rabbit
Strain:
other: New Zealand albino
Details on test animals or test system and environmental conditions:
sex: male

Test system

Type of coverage:
not specified
Preparation of test site:
not specified
Vehicle:
unchanged (no vehicle)
Controls:
not specified
Amount / concentration applied:
no data available
Duration of treatment / exposure:
single exposure
Observation period:
till 7 or 14 days
Number of animals:
no data available
Details on study design:
SCORING SYSTEM: The skin irritation potential was characterized by cutaneous primary irritation index (PII)

Results and discussion

In vitro

Other effects / acceptance of results:
no data available

In vivo

Results
Irritation parameter:
other:
Basis:
mean
Time point:
other: 7 or 14 days
Score:
6.8
Reversibility:
not specified
Remarks on result:
probability of severe irritation
Irritant / corrosive response data:
Severely irritating to rabbit skin
Other effects:
Histological examination of the skin showed necrosis, ulceration and regeneration of tissues.

Applicant's summary and conclusion

Interpretation of results:
Category 2 (irritant) based on GHS criteria
Conclusions:
The Primary Irritation index (PII) for 3-methylpyridine was 6.8. Histological examination of the skin showed necrosis, ulceration and regeneration of tissues.
Based on these observations, 3-methylpyridine can be considered to be severely irritating to rabbit skin.
Executive summary:

The dermal irritation potential of 3-methylpyridine was assessed in rabbits. Undiluted 3-methylpyridine was applied to the skin of male New Zealand albino rabbits and observed for signs of irritation till 7 or 14 days.Following 7 or 14 days rabbits were killed and histological examinations were performed on the test site.The skin irritation potential was characterized by cutaneous primary irritation index (PII).

The Primary Irritation index (PII) for 3-methylpyridine was 6.8. Histological examination of the skin showed necrosis, ulceration and regeneration of tissues.

Based on these observations, 3-methylpyridine can be considered to be severely irritating to rabbit skin.