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EC number: 219-616-8 | CAS number: 2481-94-9
Endpoint summary
Administrative data
Description of key information
Biodegradation in water
Biodegradability of 4-(Diethylamino)azobenzene (CAS no. 2481 -94 -9) is predicted using OECD QSAR toolbox version 3.3 (2017) with logKow as the primary descriptor. Test substance undergoes 14% degradation by BOD in 28 days. Thus, based on percentage degradation, the test chemical 4-(Diethylamino)azobenzene was estimated to be not readily biodegradable in water.
Biodegradation in water and sediment
Estimation Programs Interface (EPI Suite, 2017) prediction model was run to predict the half-life in water and sediment for the test compound 4-(Diethylamino)azobenzene (CAS No. 2481 -94 -9). If released in to the environment, 12.6% of the chemical will partition into water according to the Mackay fugacity model level III and the half-life period of 4 -(Diethylamino)azo benzene in water is estimated to be 60 days (1440 hrs). The half-life (60 days estimated by EPI suite) indicates that the chemical is persistent in water and the exposure risk to aquatic animals is moderate to high whereas the half-life period of 4-(Diethylamino)azobenzene in sediment is estimated to be 541.66 days (13000 hrs). Based on this half-life value, it indicates that 4-(Diethylamino)azo benzene is persistent in sediment.
Biodegradation in soil
The half-life period of 4-(Diethylamino)azobenzene (CAS No. 2481 -94 -9) in soil was estimated using Level III Fugacity Model by EPI Suite version 4.1 estimation database (EPI suite, 2017). If released into the environment, 80.4% of the chemical will partition into soil according to the Mackay fugacity model level III. The half-life period of 4-(Diethylamino)azobenzene in soil is estimated to be 120 days (2880 hrs). Based on this half-life value of 4-(Diethylamino)azobenzene, it is concluded that the chemical is not persistent in the soil environment and the exposure risk to soil dwelling animals is moderate to low.
Additional information
Biodegradation in water
Various predicted data for the target compound 4-(Diethylamino)azobenzene (CAS No. 2481-94-9) and supporting weight of evidence studies for its closest read across substance with logKow as the primary descriptor were reviewed for the biodegradation end point which are summarized as below:
In a prediction done by SSS (2017) using OECD QSAR toolbox version 3.3 with logKow as the primary descriptor, percentage biodegradability of test chemical4-(Diethylamino)azobenzene (CAS No. 2481-94-9) was estimated. Test substance undergoes 14% degradation by BOD in 28 days. Thus, based on percentage degradation, the test chemical 4-(Diethylamino)azobenzene was estimated to be not readily biodegradable in water.
In another prediction using the Estimation Programs Interface Suite (EPI suite, 2017), the biodegradation potential of the test compound4-(Diethylamino)azobenzene(CAS No. 2481-94-9) in the presence of mixed populations of environmental microorganisms was estimated.The biodegradability of the substance was calculated using seven different models such as Linear Model, Non-Linear Model, Ultimate Biodegradation Timeframe, Primary Biodegradation Timeframe, MITI Linear Model, MITI Non-Linear Model and Anaerobic Model (called as Biowin 1-7, respectively) of the BIOWIN v4.10 software. The results indicate that chemical 4-(Diethylamino)azobenzene is expected to be not readily biodegradable.
In a supporting weight of evidence study from authoritative database (J-CHECK, HSDB, 2017 and EnviChem, 2014) for the read across chemical 4,4'-bi-o-toluidine (CAS no. 119-93-7), biodegradation experiment was conducted for 28 days for evaluating the percentage biodegradability of read across substance 4,4'-bi-o-toluidine. The study was performed according to OECD Guideline 301 C (Ready Biodegradability: Modified MITI Test (I)). Concentration of inoculum i.e, sludge used was 30 mg/l and initial test substance conc. used in the study was 100 mg/l, respectively. The percentage degradation of substance 4,4'-bi-o-toluidine was determined to be 3 and 6% by BOD and HPLC parameter in 28 days. Thus, based on percentage degradation, 4,4'-bi-o-toluidine is considered to be not readily biodegradable in nature.
Another biodegradation study was conducted for 28 days for evaluating the percentage biodegradability of read across substance 2 -ethylamino-4 -isopropylamino-6 -methylthio-1,3,5 -triazine (CAS no. 834 -12 -8) (J-CHECK, 2017). Concentration of inoculum i.e, sludge used was 30 mg/l and initial test substance conc. used in the study was 100 mg/l, respectively. The percentage degradation of substance 2 -ethylamino-4 -isopropylamino-6 -methylthio-1,3,5 -triazine was determined to be 0 and 1% by BOD and HPLC parameter in 28 days. Thus, based on percentage degradation, 2 -ethylamino-4 -isopropylamino-6 -methylthio-1,3,5 -triazine is considered to be not readily biodegradable in nature.
For theread across substanceN,N-bis(2,3-epoxypropyl)anilin (CAS no. 2095-06-9) from authoritative database(J-CHECK, 2017), biodegradation study was conducted for 28 days for evaluating the percentage biodegradability of read across chemical N,N-bis(2,3-epoxypropyl)anilin. Concentration of inoculum i.e, sludge used was 30 mg/l and initial test substance conc. used in the study was 100 mg/l, respectively. The percentage degradation of substance N,N-bis(2,3-epoxypropyl)anilin was determined to be 3, 2 and 11% by BOD, TOC removal and UV-Vis parameter in 28 days. Thus, based on percentage degradation, N,N-bis(2,3-epoxypropyl)anilin is considered to be not readily biodegradable in nature.
On the basis of above results for target chemical 4 -(Diethylamino)azobenzene (from OECD QSAR toolbox version 3.3 and EPI suite, 2017) and for its read across substance (from authoritative database J-CHECK, HSDB and Envichem), it can be concluded that the test substance 4 -(Diethylamino)azobenzene can be expected to be not readily biodegradable in nature.
Biodegradation in water and sediment
Estimation Programs Interface (EPI Suite, 2017) prediction model was run to predict the half-life in water and sediment for the test compound 4-(Diethylamino)azobenzene (CAS No. 2481 -94 -9). If released in to the environment, 12.6% of the chemical will partition into water according to the Mackay fugacity model level III and the half-life period of 4 -(Diethylamino)azo benzene in water is estimated to be 60 days (1440 hrs). The half-life (60 days estimated by EPI suite) indicates that the chemical is persistent in water and the exposure risk to aquatic animals is moderate to high whereas the half-life period of 4-(Diethylamino)azobenzene in sediment is estimated to be 541.66 days (13000 hrs). Based on this half-life value, it indicates that 4-(Diethylamino)azo benzene is persistent in sediment.
Biodegradation in soil
The half-life period of 4-(Diethylamino)azobenzene (CAS No. 2481 -94 -9) in soil was estimated using Level III Fugacity Model by EPI Suite version 4.1 estimation database (EPI suite, 2017). If released into the environment, 80.4% of the chemical will partition into soil according to the Mackay fugacity model level III. The half-life period of 4-(Diethylamino)azobenzene in soil is estimated to be 120 days (2880 hrs). Based on this half-life value of 4-(Diethylamino)azobenzene, it is concluded that the chemical is not persistent in the soil environment and the exposure risk to soil dwelling animals is moderate to low.
On the basis of available information, the test substance 4-(Diethylamino)azobenzene can be considered to be not readily biodegradable in nature.
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