Registration Dossier
Registration Dossier
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EC number: 203-656-8 | CAS number: 109-21-7
Acute Toxicity: other routes
Administrative data
- Endpoint:
- acute toxicity: other routes
- Remarks:
- Intraperitoneal
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- documentation insufficient for assessment
Data source
Reference
- Reference Type:
- publication
- Title:
- Relation of the toxicity of some homologous esters to their rates of saponification.
- Author:
- Selisko
- Year:
- 1 962
- Bibliographic source:
- Ernahrungsforschung, 7(2), 211-215
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- The median lethal dose of various esters was determined in rats after intraperitoneal injections. The animals were observed for 24 hours and the method was according to Behrens and Kärber.
- GLP compliance:
- not specified
- Limit test:
- no
Test material
- Reference substance name:
- Butyl butyrate
- EC Number:
- 203-656-8
- EC Name:
- Butyl butyrate
- Cas Number:
- 109-21-7
- Molecular formula:
- C8H16O2
- IUPAC Name:
- butyl butanoate
- Test material form:
- liquid
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: own breed
- Weight at study initiation: 90 +/- 5 g
- Fasting period before study: yes
Administration / exposure
- Route of administration:
- intraperitoneal
- Vehicle:
- not specified
- Doses:
- 6-7 groups up to 5000 mg/kg bw, however, not specified.
- No. of animals per sex per dose:
- 8
- Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: 24 hours
- Statistics:
- Determination of LD50 according to formula Behrens and Kärber.
Results and discussion
Effect levels
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 2 200 mg/kg bw
- Based on:
- test mat.
- Mortality:
- No detailed information given.
- Clinical signs:
- No detailed information given.
Applicant's summary and conclusion
- Conclusions:
- The LD50 after intraperitoneal injection was determined to be 2200 mg/kg bw.
- Executive summary:
In the current study the toxicity of the test item was assessed and the median lethal dose (LD50) was determined.
The undiluted test material was administered to albino rats via intraperitoneal route. The animals were fasted before treatment and observed for 24 hours after injections. In every group there were 8 animals and for the determination of the LD50 6 -7 groups were taken.
The LD50 was determined to be 2200 mg/kg bw. No further details were given.
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