Registration Dossier
Registration Dossier
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EC number: 246-874-9 | CAS number: 25340-17-4
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1957
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: The study was performed before GLP. Limited information is available on study animals or test conditions.
Cross-referenceopen allclose all
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to other study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 957
- Report date:
- 1957
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Three male rats/dose level were exposed to saturated atmospheres of 1400 ppm (bath temperature-room temperature) or 2100 ppm (bath temperature- 100C).
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Diethylbenzene
- EC Number:
- 246-874-9
- EC Name:
- Diethylbenzene
- Cas Number:
- 25340-17-4
- Molecular formula:
- C10H14
- IUPAC Name:
- diethylbenzene
- Details on test material:
- IUCLID4 Test substance: other TS: Dowtherm J mixed isomers
Dowtherm J mixed isomers
Composition: 25% ortho, 40% meta and 35% Para
Boiling point: 180-184F at 760
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- No additional data
Administration / exposure
- Route of administration:
- inhalation
- Type of inhalation exposure:
- other: No data but typically whole body exposure for this teime period.
- Vehicle:
- not specified
- Details on inhalation exposure:
- No data
- Analytical verification of test atmosphere concentrations:
- no
- Duration of exposure:
- 7 h
- Concentrations:
- 1400 ppm(saturated vapors at room temperature) or 2100 ppm (saturated atmosphere at bath temperature of 100C)
- No. of animals per sex per dose:
- 3 male rats/dose
- Control animals:
- no
- Details on study design:
- No additional data
- Statistics:
- None
Results and discussion
- Preliminary study:
- Not applicable
Effect levelsopen allclose all
- Sex:
- male
- Dose descriptor:
- LC50
- Effect level:
- > 1 400 ppm
- Based on:
- test mat.
- Exp. duration:
- 7 h
- Remarks on result:
- other: Saturated atmosphere at room temprature. (Equivalent to >7800 mg/m3)
- Sex:
- male
- Dose descriptor:
- LC50
- Effect level:
- > 2 100 ppm
- Based on:
- test mat.
- Exp. duration:
- 7 h
- Remarks on result:
- other: Saturated atmosphere (100C bath)
- Mortality:
- All rats survived a seven hour (1400 ppm) exposure to saturated atmosphere of DEB mixed isomers generated at room temperature. All rats survived a seven hour (2100 ppm) exposure to saturated atmosphere of DEB mixed isomers generated at 100C bath temperature.
- Clinical signs:
- other: 1400 ppm- Very slight nasal irritation. Slightly drowsy on removal after exposure. 2100 ppm- Slight nasal irritation, drowsy on removal after exposure.
- Body weight:
- 1400 ppm- Slight to moderate weight loss
2100 ppm- Moderate weight loss, diarrhea - Gross pathology:
- 1400 ppm- Blue colors in all tissues and secretion, Slight kidney pathology, very slight liver in jury.
2100 ppm- All tissues and secretion were blue. Moderate kidney pathology, very slight liver injury.
Note: This blue color has been seen in rats exposed to vapors and rats which have been fed diethyl benzene. Whether the blue color is injurious or merely a cosmetic effect is not known. - Other findings:
- None
Any other information on results incl. tables
None
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- LC50>2100 ppm (saturated vapors) or > 11.52 mg/L for a 7 hour exposure in rats.
- Executive summary:
Groups of 3 male rats were exposed to 1400 ppm (saturated vapors at room temperature) or 2100 ppm (saturated atmosphere at bath temperature of 100C) for 7 hours.
The LC50 in rats following a 7 hour exposure of saturated atmosphere to rats was >2100 ppm or >11.52 mg/L.
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