Registration Dossier
Registration Dossier
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EC number: 601-478-9 | CAS number: 117428-22-5
Vapour pressure
Administrative data
Link to relevant study record(s)
- Endpoint:
- vapour pressure
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 104 (Vapour Pressure Curve)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.4 (Vapour Pressure)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 830.7950 (Vapor Pressure)
- Deviations:
- no
- GLP compliance:
- yes
- Type of method:
- gas saturation method
- Key result
- Test no.:
- #1
- Temp.:
- 40 °C
- Vapour pressure:
- 0.049 other: mPa
- Key result
- Test no.:
- #2
- Temp.:
- 45 °C
- Vapour pressure:
- 0.098 other: mPa
- Key result
- Test no.:
- #3
- Temp.:
- 50 °C
- Vapour pressure:
- 0.165 other: mPa
- Key result
- Test no.:
- #4
- Temp.:
- 20 °C
- Vapour pressure:
- 0.003 other: mPa
- Remarks on result:
- other: Calculated
- Key result
- Test no.:
- #5
- Temp.:
- 25 °C
- Vapour pressure:
- 0.007 other: mPa
- Remarks on result:
- other: Calculated
- Conclusions:
- The measured vapour pressure of the test substance at 40, 45 and 50°C was 0.0491, 0.0975 and 0.1647 mPa, respectively. The calculated vapour pressure of the test substance at 20 and 25°C was 0.0034 mPa (3.4 × 10e-6 Pa) and 0.0069 mPa (6.9 × 10e-6 Pa), respectively.
- Executive summary:
This study was conducted to determine the vapour pressure of the test substance. The vapour pressure was determined according to the regulatory guidelines: OPPTS 830.7950, EEC A.4, and OECD 104 employing the gas saturation method.
The vapour pressure of the test item was determined at three gas flow rates (approximately 35, 45 and 55 mL/min) and at three temperatures (40, 45 and 50°C). The analysis of active ingredient was conducted using a validated HPLC method. The mean vapour pressure values were 0.0491, 0.0975 and 0.1647 mPa at 40, 45 and 50°C, respectively. A vapour pressure curve was plotted using inverse value of experimental temperature in K (1/T) on X- axis and VP on Y-axis. The vapour pressure of the test item at 20 and 25°C was calculated using slope and intercept of the regression line. The vapour pressure of test item at 20 and 25°C were 0.0034 and 0.0069 mPa (3.4 × 10e-6 and 6.9 × 10e-6 Pa), respectively.
Reference
Description of key information
OECD Guideline 104
Key value for chemical safety assessment
- Vapour pressure:
- 3 400 Pa
- at the temperature of:
- 20 °C
Additional information
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