Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 601-478-9
CAS number: 117428-22-5
Male and female rats were administered a
single oral dose of 10 mg/kg of the 14C radiolabeled pyridyl or phenyl
moiety of the test substance. The excretion of radioactivity was
monitored in urine, feces and exhaled air. Twenty-four hours after
dosing, the rats were killed to investigate the distribution of
radioactivity using whole body autoradiography (WBA).
Twenty-four hours after dosing with the
[14C]-pyridyl moiety, the male rat excreted 21.0% of the administered
dose in the urine and 13.4% in the feces. The similarly dosed female rat
excreted 25.0% of the dose in the urine and 19.1% in the feces over the
same period. For both sexes, less than 0.4% of the administered dose was
exhaled as volatile metabolites over 24 hours after dosing. In the WBA
sections, the majority of the radioactivity was observed in the
intestinal tract contents of both
sexes. Tissue radiolabeling was apparent in the liver with lower levels in
the kidneys. Lower intensities of radioactivity were observed in all
Twenty-four hours after dosing with
[14C]-phenyl moiety, the male rats excreted 17.8% of the administered
dose in the urine and 19.6% in the feces. The female rats excreted 30.2%
of the administered dose in the
urine and 19.6% in the feces over the same period. For both sexes, less than
0.1% of the dose was exhaled as volatile metabolites. In the WBA
sections, the highest intensity
of radioactivity was observed in the gastrointestinal tract contents of
both sexes and also the stomach
mucosa of the male rat. Tissue radiolabelling was apparent in the liver
and kidneys, with lower
intensities of radioactivity observed in all other tissues.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
Welcome to the ECHA website. This site is not fully supported in Internet Explorer 7 (and earlier versions). Please upgrade your Internet Explorer to a newer version.
Do not show this message again