Lavender, Lavandula angustifolia, ext.

Boiling point

Link to relevant study record(s)

Reference

Endpoint:

boiling point

Type of information:

experimental study

Adequacy of study:

key study

Study period:

September 2016

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Justification for type of information:

The study was conducted according to an internationally recognised method, and under GLP. The test substance is adequately characterised. Therefore full validation applies.

Qualifier:

according to guideline

Guideline:

EU Method A.2 (Boiling Temperature)

Deviations:

no

Qualifier:

according to guideline

Guideline:

OECD Guideline 103 (Boiling point/boiling range)

Deviations:

no

GLP compliance:

yes (incl. QA statement)

Remarks:

inspected on 13 and 14 October 2014 / signed on 08 April 2015

Type of method:

method according to Siwoloboff

Key result

Boiling pt.:

ca. 172 °C

Atm. press.:

ca. 101 325 Pa

Remarks on result:

other: Mean ± standard deviation (after correction following Sydney Young) = 172.0 ± 0.2 °C (445.2 ± 0.2 K) at standard pressure (101.325 kPa).

Results

Observations and measured values are presented in the following table.

Table 4.3/2-Results

Determination	Boiling Point	Atmospheric Pressure
First determination	171.3 °C (444.5 K)	99678 Pa
Second determination	171.3 °C (444.5 K)	98891 Pa

In both determinations bubbles were immediately visible. At 212.4 °C a boiling chain was observed, the heating switched off. After cooling down the test item was visible unchanged.

 

For the calculation of the value of the mean and the evaluation, only the results of repetition were taken.

Table 4.3/3.-Corrected values following Sidney-Young

	Boiling point	Pressure in Pa	Corrected Boling point
First determination	171.3 °C (444.5 K)	99678 Pa	171.90 °C (445.05 K)
Second determination	171.3 °C (444.5 K)	98891 Pa	172.19 °C (445.34 K)
Mean			172.0 °C (445.2 K)

 

Mean ± standard deviation (after correction following Sydney Young) = 172.0 ± 0.2 °C (445.2 ± 0.2 K) at standard pressure (101.325 kPa).

Conclusions:

The initial boiling point of the test item was determined following the SIWOLOBOFF method as 172.0 ± 0.2 °C (445.2 ± 0.2 K), corrected to standard pressure (101.325 kPa).

Executive summary:

The initial boiling point of the test item was measured under GLP according to OECD 103 / EU A2 guideline, by Siwoloboff.

At first, three experiments were performed using the standard procedure, which yields no reliable results. Strong fluctuating of the measured values was observed. Therefore the performance was repeated with partially closed sample tubes under argon.

For the increase of the temperature, a temperature gradient of 1 °C /min was maintained. When bubbles rose constantly on the capillary, heating was turned down, and, cooling slowly. The moment at which the chain of bubbles broke was recorded (with its atmospheric pressure) as boiling point. The determination was performed in duplicate with fresh samples. The test item showed visibly no signs of change after the study.

The initial boiling point of the test item was determined as 172.0 ± 0.2 °C (445.2 ± 0.2 K), corrected to standard pressure (101.325 kPa).

Description of key information

The initial boiling temperature of the test item has been determined to be ca 172.0± 0.2°C, corrected to standard pressure (101.325 kPa).

Key value for chemical safety assessment

Boiling point at 101 325 Pa:

172 °C

Additional information

A fully reliable experimental study, conducted according to a recognized OECD/EC method and under GLP, is available. It is considered as a key study.

The initial boiling point of the test item was measured using the Siwoloboff method with partially closed sample tubes under argon.

For the increase of the temperature, a temperature gradient of 1 °C /min was maintained. When bubbles rose constantly on the capillary, heating was turned down, and, cooling slowly. The moment at which the chain of bubbles broke was recorded (with its atmospheric pressure) as boiling point. The determination was performed in duplicate with fresh samples. The test item showed visibly no signs of change.