Registration Dossier
Registration Dossier
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EC number: 233-343-1 | CAS number: 10124-56-8
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- abstract
- Justification for type of information:
- A scientific review, data insufficient for assesment.
Data source
Reference
- Reference Type:
- review article or handbook
- Title:
- Final Report on the Safety Assessment of Sodium Metaphosphate, Sodium Trimetaphosphate, and Sodium Hexametaphosphate
- Author:
- Reviewed by the Cosmetic Ingredient Review Expert Panel.
- Year:
- 2 001
- Bibliographic source:
- International Journal of Toxicology, p 75-89.
Materials and methods
- Principles of method if other than guideline:
- Standard Draize dermal irritation assay.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Sodium metaphosphate
- EC Number:
- 233-343-1
- EC Name:
- Sodium metaphosphate
- Cas Number:
- 10124-56-8
- Molecular formula:
- Na6O18P6
- IUPAC Name:
- hexasodium 2,4,6,8,10,12-hexaoxocyclohexaphosphoxane-2,4,6,8,10,12-hexakis(olate)
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- not specified
Results and discussion
In vivo
Results
- Remarks on result:
- other: All rabbits of this group had erythema and edema scores of 4 (severe) for both intact and abraded skin sites at 24 and 72 hours
Any other information on results incl. tables
All rabbits of this group had erythema and edema scores of 4 (severe) for both intact and abraded skin sites at 24 and 72 hours.
Applicant's summary and conclusion
- Interpretation of results:
- study cannot be used for classification
- Conclusions:
- All rabbits of this group had erythema and edema scores of 4 (severe) for both intact and abraded skin sites at 24 and 72 hours.
- Executive summary:
Sodium Hexametaphosphate (concentration not specifed) had the maximum primary irritation index (PII) score of 8.0 in the standard Draize dermal irritation assay using six rabbits. All rabbits of this group had erythema and edema scores of 4 (severe) for both intact and abraded skin sites at 24 and 72 hours.
Information poorly documented, insuficient for classification.
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