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EC number: 205-159-1 | CAS number: 134-84-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1998-1999
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Justification for type of information:
- Justification of Read-across
Currently, the availability of reliable data on 4-Methylbenzophenone is insufficient to enable the assessment of this substance with respect to its toxicological effects. However, much more information is available on benzophenone, a substance with a closely related chemical structure. 4-Methylbenzophenone and benzophenone are aromatic ketones with a comparable molecular weight (196 or 182 g/mol, respectively). Both substances share a conjugated structure, with a carbonyl group bridging two phenyl rings. The only difference is an additional methyl group in 4-Methylbenzophenone.
4-Methylbenzophenone is expected to be metabolised by the same metabolic pathways as benzophenone, with the addition of oxidation of the 4-methyl group to the corresponding alcohol and further oxidation to the carboxylic acid with its glycine and glucuronide conjugates.
From these considerations, it is very likely that 4-methylbenzophenone will also exhibit very similar effects as benzophenone. Therefore, and furthermore with respect to animal welfare, the performance of any new experimental tests on 4-methylbenzophenone is assumed to be not justifiable. Instead, results from reliable key studies performed with benzophenone can be regarded as a sound basis for assessing possible toxicological properties of 4-methylbenzophenone.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 999
- Report date:
- 1999
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.4 (Acute Toxicity: Dermal Irritation / Corrosion)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Remarks:
- Scantox, Lille Skensved, Denmark
Test material
- Reference substance name:
- Benzophenone
- EC Number:
- 204-337-6
- EC Name:
- Benzophenone
- Cas Number:
- 119-61-9
- Molecular formula:
- C13H10O
- IUPAC Name:
- benzophenone
- Details on test material:
- - Name of test material (as cited in study report): HR 98/660032
- Physical state: white to pale yellowish crystals
- Lot/batch No.: 50391499
- Expiration date of the lot/batch: Dec 1999
- Storage condition of test material: in refrigerator in the dark
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- other: MOL:Russian
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: M&B, Ejby, DK-4623 Lille Skensved, Denmark
- Weight at study initiation: 2.2-2.4 kg
- Housing: individual in PPO/HIPS cages
- Diet : ad libitum
- Water : ad libitum
- Acclimation period: 5 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20 +- 3°C
- Humidity (%): 55 +- 15%
- Air changes (per hr): 10/hour
- Photoperiod (hrs dark / hrs light): 12/12
IN-LIFE DATES: From 14 Dec 1998 To: 01 January 1999
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- shaved
- Vehicle:
- other: Ethanol 96% and Diethyl phthalate (1:1)
- Controls:
- not required
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.5 g of the test item was moistened with 0.5 mL vehicle, or 0.5 mL of the test article solution (if diluted), were applied
- Concentration (if solution): 2, 5, 10, 25 and 100%
VEHICLE
- Amount(s) applied (volume or weight with unit): 0.5 mL - Duration of treatment / exposure:
- 4 hours
- Observation period:
- 1 hour after exposure period as well as 24, 48 and 72 hours after exposure period
- Number of animals:
- 4
- Details on study design:
- TEST SITE
- Area of exposure: 10x10 cm, 6 sites were selected on this area
- Type of wrap if used: gauze patches secured with 2.5 cm adhesive tapes
REMOVAL OF TEST SUBSTANCE
- Washing (if done): yes, with lukewarm water and mild soap
- Time after start of exposure: 4 hours after exposure
SCORING SYSTEM: Erythema and Eschar formation: Score 0 to 4; Oedema formation: Score 0 to 4
Results and discussion
In vivo
Results
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- other: 24, 48 and 72 hours
- Score:
- 0
- Max. score:
- 0
- Reversibility:
- fully reversible
- Irritant / corrosive response data:
- No signs of irritations were observed at any of the concentrations tested
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- All treated skin sites were scored with 0, i.e. no irritation was induced at any of the tested concentrations. Benzophenone is therefore not subject of classification.
- Executive summary:
A primary skin irritation study was performed in rabbits according to OECD 404 (1992). Benzophenone was tested at concentrations of 2, 5, 10, 25 and 100%. No signs of skin irritation were observed at any of the concentrations tested. Therefore, no classification as skin irritant is required.
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